Relationship between glycosylated hemoglobin and lipid metabolism in patients with type 2 diabetes
April 17, 2010
| Abstract Title: | Relationship between glycosylated hemoglobin and lipid metabolism in patients with type 2 diabetes |
| Authors: | Crisnic Ioan1, Gligor Ramona1, Mariş Lavinia1, Ghinga Simona2 |
| Affiliation: | 1 Biochemistry Department, Faculty of Medicine, Pharmacy and Dental Medicine, “Vasile Goldis” Western University Arad, Romania 2 S.C. Laborator Analize S.R.L. Arad |
| Abstract text: | Diabetic patients with accompanied dyslipidemia are soft targets of cardiovascular deaths. An early intervention to normalize plasmatic lipids has been shown to reduce cardiovascular complications and mortality at type 2 diabetic patients. Glycated hemoglobin (HbA1c) is a used marker for long term glycemic control. This investigation is an attempt to evaluate the diagnostic value of hemoglobin HbA1c in predicting diabetic dyslipidemia. Venous blood was collected from 112 type 2 diabetic patients ages 30-75 years, male/female, ratio 1.02. The sera were analyzed for HbA1c, basal blood glucose, total cholesterol, triglycerides high density lipoprotein cholesterol (HDL cholesterol) and low density lipoprotein cholesterol (LDL cholesterol). The levels of HbA1c did not differ significantly between males and females. HbA1c showed direct and significant correlations with cholesterol, triglycerides and LDL and reverse correlation with HDL. Female diabetic patients had significantly higher levels of serum cholesterol and HDL compared to males. There were no significant differences in triglycerides and LDL between the two genders. There was a significant increase in triglycerides in the patients of both genders with impaired glycemic control. Both male and female patients with worse glycemic control (HbA1c > 9%) had significantly high cholesterol and LDL levels. Serum HDL showed a significant and inverse relationship with uncontrolled hyperglycemia in females but not in males. These findings clearly suggest that HbA1c can provide valuable supplementary information about the extent of circulating lipids besides its primary role in monitoring long term glycemic control. Further studies are warranted to reinforce the potential of HbA1c as a biomarker for screening of high-risk diabetic patients. |
| Keywords: | type 2 diabetes, dyslipidemia, glycemic control, HbA1c |
| Presentation type: | Oral |
| Correspondence: | no. 1 Feleacului St., Arad, Romania |
| Email: | ramona_gligor@yahoo.com |
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