HISTOPATHOLOGICAL FEATURES IN CHRONIC PANCREATITIS

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Article Title:	HISTOPATHOLOGICAL FEATURES IN CHRONIC PANCREATITIS
Authors:	Carmen Neamţu1 Cristian Nica2, Vladimir Hotineanu3 Coralia Cotoraci1, Aurel Ardelean1, Bogdan Totolici1
Affiliation:	1„Vasile Goldiş” Western University of Arad – Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania 2“Victor Babeş“ University of Medicine and Pharmacy – Timişoara, Romania 3State’s University of Medicine “ Nicolae Testemiţanu “ Chişinău, Republic of Moldova
Abstract:	We present the results of a prospective and retrospective study conducted in the last 10 years in three Universities of Medicine (Arad’s and Timisoara’s Universities of Medicine from Romania and Chisinau’s University of Medicine from Republic of Moldova). The results are based on clinical and paraclinical data collected from 53,03% of the entire lot of patients diagnosed with chronic pancreatitis admitted in the surgical departments of the aforementioned universities. The patients were distributed in two groups, according to the aetiology of the chronic pancreatitis: obstructive and non-obstructive chronic pancreatitis. The age of the patients varied from 17 to 65 years, with a mean age of 45 years. Intraoperatory pancreatic tissue was prelevated from all patients and sent for histopathological analysis. All patients signed the informed consent. Structural modifications of the pancreatic acinar cells were noticed, evidence of different degrees of functional activity, dystrophic modifications and cellular dysfunction being also found. Concomitantly, alongside dystrophic intracellular modifications we noticed destructive disorders of the acinar basal membrane and of the cellular membranes.
Keywords:	chronic lithiasic pancreatitis, morphological, histopathological changes
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*Correspondence:	Cristian Nica “Victor Babeş“ University of Medicine and Pharmacy Timişoara, Romania Mobile: 0723225793