Antibiotic sensitivity versus antibiotic resistance in Escherichia Coli urinary tract infections…
March 29, 2010
| Abstract Title: | Antibiotic sensitivity versus antibiotic resistance in Escherichia Coli urinary tract infections in hospitalized children from Arad County – a 4 years study |
| Authors: | Simona Dumitra*, Liana Precup*, Dorin Lazar*, Alin Iacob Ali**, Ramona Ali** |
| Affiliation: | * “Vasile Goldis” Western University of Arad, Romania ** Clinical Hospital of Timisoara, Romania |
| Abstract text: | Background: E. coli is the major bacteria incriminated in urinary tract infection in children. The local pattern of E. coli antibiotic sensitivity and antibiotic resistance is essential in the optimal therapy. Objectives: The aim of the study was to establish a local guideline in urinary tract infection with E. coli in hospitalized children in Arad County based upon the variation of antibiotic sensitivity and antibiotic resistance of this bacterial pathogen. Methods: The group consisted of 82 E. coli strains, isolated from children with acute urinary tract infections. The children were admitted in the Pediatric Clinic of Arad during a period of 4 years, from January 2006 to December 2009. The retrospective study used clinical data. The diffusimetric antibiotic test was performed according to the existing standards at the moment. The antibacterial drugs most frequently used in the antibiotic sensitivity testing were selected: Nalidixic Acid, Colistin, Gentamicin, Amikacin, Cephalexin, Amoxicillin and Clavulanic Acid, Co-trimoxazole, Fluoroquinolones (Ciprofloxacin, Norfloxacin, Ofloxacin), Nitrofurantoin, Ampicillin. Results: The E. coli strains developed the highest sensitivity for Norfloxacin (69.51%), ciprofloxacin (67.07%), Ofloxacin (67.07%), Gentamicin (63.41%) and Nitrofurantoin (60.97%). The lowest sensitivity was noticed for Ampicillin (0%), Cephalexin (8.53%) and Colistin (13.41%). A high resistance was confirmed for Colistin (58.53%), Amoxicillin and Clavulanic Acid (40.24%) and Co-trimoxazole (32.92%) and Ampicillin (30.48%). The lowest resistance for E. coli had Amikacin (0%), Norfloxacin (4.87%) and Nitrofurantoin (4.87%). Conclusions: 1) The Fluoroquinolones, Gentamicin and Nitrofurantoin have the maximum therapeutic benefit; 2) It is necessary to stop using the antibiotics that induce high resistance in our region (Ampicillin, Colistin, Co-trimoxazole and Amoxicillin with Clavulanic Acid); 3) The increase of the antibiotic resistance of the E. coli strains in Arad County is an alarming phenomenon. |
| Keywords: | urinary tract infection, child, Escherichia coli, antibiotic sensitivity, antibiotic resistance |
| Presentation type: | Poster |
| Correspondence: | Pediatric Clinic, Emergency Clinical County Hospital, no. 1-3 Victoriei St., Arad, Romania |
| Email: | dumitrasimona@yahoo.com |
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