EVALUATION OF FECAL IMMUNOCHEMICAL TESTS FOR COLORECTAL CANCER DETECTION.

EVALUATION OF FECAL IMMUNOCHEMICAL TESTS FOR COLORECTAL CANCER DETECTION.

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Title: EVALUATION OF FECAL IMMUNOCHEMICAL TESTS FOR COLORECTAL CANCER DETECTION.
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Article_Title: EVALUATION OF FECAL IMMUNOCHEMICAL TESTS FOR COLORECTAL CANCER DETECTION.
Authors: Iovănescu Dana1, Carmen Neamtu1*, Miuţescu Eftimie1, Miutescu Bogdan Petru1, Burlea Amelia, Ciprian Duta3, Bogdan Totolici1
Affiliation: 1„Vasile Goldiş” Western University of Arad – Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
2Department of Pathology, County Hospital Arad, Romania
3„ Victor Babes” University of Medicine and Pharmacy Timisoara, Second Surgical Clinic, Timisoara, Romania
Abstract: Colorectal cancer is the second leading cause of cancer-related death in the Western industrialized world. Early detection by screening programmes has the power to improve control of the disease. Between 1 November 2011 and 31 December 2014, 2204 patients performed fecal immunochemical tests. In 198 (8.98%) patients with a mean age of 64.8 years the result of the fecal immunochemical tests was positive. In our group we had a rather low adherence to the follow -up colonoscopy, only 97 performed colonoscopy .In 26 patients (26.8%) cancer was found and in 30 (30.92%) polyps were found. Patients with cancer and polyps tend to be older than the other patients. In our group no cancer or polyp was detected in patients younger than 50 years. Hence we consider that the age of 50 for beginning the colorectal cancer screening is suitable for our area. Fecal immunochemical test can be an important tool in detection of colorectal carcinoma and preneoplastic lesions and efforts had to be made in order to run a screening programme
Keywords: screening, colorectal carcinoma, adenoma, colonoscopy, fecal immunochemical test
References: 1.FerlayJ, Parkin DM, Steliarova-Foucher E, Estimates of cancer incidence and mortality in Europe in 2008, Eur J Cancer, vol 46, no 4,pp 765-781
2. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990;61:759–767.
3.Miutescu B, Sporea I, Popescu A, Bota S, Iovănescu D, Burlea A, Mos L, Miutescu E
Results of faecal immunochemical test for colorectal cancers creening, in average risk population, in a cohort of 1389 subjects Clujul Medical 2013 Vol. 86 – no. 2
4.Miutescu B, Sporea I, Popescu A, Bota S, Iovănescu D, Miutescu E
Adherence to a colorectal cancer screening using the faecal immunochemical test Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii Vol. 23, issue 2, 2013, pp. 111-114
5.U.S. Preventive Services Task Force Screening for Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med. 2008;149:627-637
6. Segnan N, Patnick J, van Karsa L European guidelines for quality assurance in colorectal cancer screening and diagnosis –first edition
7.Kahl CJ, Imperiale TF, Juliar BE, Rex DK. Effect of screening colonoscopy on colorectal cancer incidence and mortality, Clin. Gastroenterol.Hepatol., vol.7, 7, 770-775, 2009.
8.Levi Z, Birkenfeld S, Vilkin A et al.: A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. A prospective, controlled, feasibility study, Int. J. Cancer: 128, 2415– 2424, 2011.
9.Morikawa T, Kato J, Yamaji Y, Wada R, Mitsushima T, Shiratori Y: A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population. Gastroenterology; 129:422–428, 2005.
10.Popescu A, Sporea I: Screeningul cancerului de colon între ideal şi posibilităţi. Editura Mirton, Timişoara, 2009; 9-20, 45-103
Read_full_article: pdf/vol17/iss3-4/6 JMA 2014 – Iovanescu – EVALUATION OF FECAL IMMUNOCHEMICAL TESTS.pdf
Correspondence: Carmen Neamtu
Str. Gradinarilor Nr.43
Arad, Romania
Mobile: 0723225793
Mail: carmen.neamtu@gmail.com

Read full article
Article Title: EVALUATION OF FECAL IMMUNOCHEMICAL TESTS FOR COLORECTAL CANCER DETECTION.
Authors: Iovănescu Dana1, Carmen Neamtu1*, Miuţescu Eftimie1, Miutescu Bogdan Petru1, Burlea Amelia, Ciprian Duta3, Bogdan Totolici1
Affiliation: 1„Vasile Goldiş” Western University of Arad – Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
2Department of Pathology, County Hospital Arad, Romania
3„ Victor Babes” University of Medicine and Pharmacy Timisoara, Second Surgical Clinic, Timisoara, Romania
Abstract: Colorectal cancer is the second leading cause of cancer-related death in the Western industrialized world. Early detection by screening programmes has the power to improve control of the disease. Between 1 November 2011 and 31 December 2014, 2204 patients performed fecal immunochemical tests. In 198 (8.98%) patients with a mean age of 64.8 years the result of the fecal immunochemical tests was positive. In our group we had a rather low adherence to the follow -up colonoscopy, only 97 performed colonoscopy .In 26 patients (26.8%) cancer was found and in 30 (30.92%) polyps were found. Patients with cancer and polyps tend to be older than the other patients. In our group no cancer or polyp was detected in patients younger than 50 years. Hence we consider that the age of 50 for beginning the colorectal cancer screening is suitable for our area. Fecal immunochemical test can be an important tool in detection of colorectal carcinoma and preneoplastic lesions and efforts had to be made in order to run a screening programme
Keywords: screening, colorectal carcinoma, adenoma, colonoscopy, fecal immunochemical test
References: 1.FerlayJ, Parkin DM, Steliarova-Foucher E, Estimates of cancer incidence and mortality in Europe in 2008, Eur J Cancer, vol 46, no 4,pp 765-781
2. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990;61:759–767.
3.Miutescu B, Sporea I, Popescu A, Bota S, Iovănescu D, Burlea A, Mos L, Miutescu E
Results of faecal immunochemical test for colorectal cancers creening, in average risk population, in a cohort of 1389 subjects Clujul Medical 2013 Vol. 86 – no. 2
4.Miutescu B, Sporea I, Popescu A, Bota S, Iovănescu D, Miutescu E
Adherence to a colorectal cancer screening using the faecal immunochemical test Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii Vol. 23, issue 2, 2013, pp. 111-114
5.U.S. Preventive Services Task Force Screening for Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med. 2008;149:627-637
6. Segnan N, Patnick J, van Karsa L European guidelines for quality assurance in colorectal cancer screening and diagnosis –first edition
7.Kahl CJ, Imperiale TF, Juliar BE, Rex DK. Effect of screening colonoscopy on colorectal cancer incidence and mortality, Clin. Gastroenterol.Hepatol., vol.7, 7, 770-775, 2009.
8.Levi Z, Birkenfeld S, Vilkin A et al.: A higher detection rate for colorectal cancer and advanced adenomatous polyp for screening with immunochemical fecal occult blood test than guaiac fecal occult blood test, despite lower compliance rate. A prospective, controlled, feasibility study, Int. J. Cancer: 128, 2415– 2424, 2011.
9.Morikawa T, Kato J, Yamaji Y, Wada R, Mitsushima T, Shiratori Y: A comparison of the immunochemical fecal occult blood test and total colonoscopy in the asymptomatic population. Gastroenterology; 129:422–428, 2005.
10.Popescu A, Sporea I: Screeningul cancerului de colon între ideal şi posibilităţi. Editura Mirton, Timişoara, 2009; 9-20, 45-103
*Correspondence: Carmen Neamtu
Str. Gradinarilor Nr.43
Arad, Romania
Mobile: 0723225793
Mail: carmen.neamtu@gmail.com