Pancreatic cancer – Molecular profile
March 28, 2010
| Abstract Title: | Pancreatic cancer – Molecular profile |
| Authors: | Carmen Neamtu |
| Affiliation: | “Vasile Goldis” Western University of Arad, Romania, Emergency Clinical County Hospital, Arad, Romania |
| Abstract text: | This study represents an interdisciplinary approach of pancreatic cancer, using immunohistochemical research, in order to establish early diagnosis (molecular profile of neoplastic pancreatic cells) and to initiate a complex personalized surgical / oncologic treatment. Genetic molecular profile can differentiate subtypes of pancreatic cancers. It offers biomarkers for early detection of these subtypes. Also early detection and specific treatment can be achieved using genomic probes that expose trigger-genes for pancreatic cancer. Histopathologic examination reveals specific peritumoral stromal reaction, that leads to important data for treatment. Because of the existent double subgroups of pancreatic neoplasm endocrine and exocrine and of the multiple anatomic and clinic forms (serous and mucous cystadenocarcinoma, insulinoma, gastrinoma, glucagonoma) in the gastrinoma of the island cells we can see different grades of malignancy – neoplastic invasion – that were established with the help of histochemical fixation of mucinei glycogen and determination of appurtenance to the family PAS (PAS d positive intra cellular globules may be present), immunohystology (alpha 1-antitrypsin, antichymotrypsin, neuron-specific enolase,vimentin, progesterone receptors, beta-catenin, CD10, CD56, FLI1, galectin-3, keratin, synaptophysin, CD34, estrogen receptor, chromogranin) and molecular genetics (EWS/SLI-1 translocation not present even though SLI-1 positive by immunohistochemistry). Genetic molecular profile can differentiate the pancreatic cancer. |
| Keywords: | pancreatic cancer, molecular profile, early detection, treatment |
| Presentation type: | Oral |
| Correspondence: | no. 43 Gradinarilor St., Arad, Romania |
| Email: | carmen.neamtu@gmail.com |
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