THE PROGNOSTIC ROLE OF MAST CELLS ACCORDING WITH THE HISTOLOGICAL GROWTH PATTERN IN LIVER METASTASIS OF TUMORS WITH DIGESTIVE ORIGINS
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| Article Title: | THE PROGNOSTIC ROLE OF MAST CELLS ACCORDING WITH THE HISTOLOGICAL GROWTH PATTERN IN LIVER METASTASIS OF TUMORS WITH DIGESTIVE ORIGINS |
| Authors: | 1,2Ciolofan A, 2*Ceausu AR, 2Gaje NP, 2Tudor AM, 1Cretu O , 3Nicolescu A |
| Affiliation: | 1”Victor Babes” University of Medicine and Pharmacy, Department of Surgery, Timisoara, Romania, 2 “Victor Babes” University of Medicine and Pharmacy, Department of Microscopic Morphology/ Histology, Angiogenesis Research Center Timisoara, Romania, 3„Vasile Goldis” Western University of Arad, Romania, Department of Intensive Care. |
| Abstract: | Despite the significant progress regarding molecular classifications for colon, pancreatic and gastric cancer, the therapeutic methods (arterial, chimio and radioembolization), the life expectancy of patients with existing liver metastases did not improve significantly. The aim was to analyze the interrelation between the vascularization, mast cells and the histological growth pattern of hepatic metastasis with digestive origins. 25 patients were evaluated by ways of the immunohistochemical technique. The distribution of the liver metastasis growth pattern was as follows: colon (all 3 types), pancreatic (replacement), gastric (pushing type). A significant correlation between mast cell density in the peritumoral area and vascular microdensity in the metastatic domain of all histological growth patterns was found. Significant correlation between positive mast cells tryptase density and degree of differentiation for the desmoplastic type was noticed. The mast cells may have a prognostic role in this growth pattern and the mast cell inhibitor therapy may be useful. |
| Keywords: | mast cells, liver metastasis, histological growth pattern |
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| *Correspondence: | • CIOLOFAN ALEXANDRU, MD, PhD student ”Victor Babes” University of Medicine and Pharmacy, Department of Surgery Piata Eftimie Murgu no. 2, 300041, Timisoara, Timis, Romania, Phone: 004025620447 • CEAUSU AMALIA RALUCA*, MD, PhD, Lecturer ”Victor Babes” University of Medicine and Pharmacy, Department of Microscopic Morphology/ Histology, Angiogenesis Research Center, Timisoara Piata Eftimie Murgu no. 2, 300041, Timisoara, Timis, Romania, Phone: 0040740872707 e-mail: ra.ceausu@umft.ro • GAJE NELA PUSA, MD, PhD, Associate Professor ”Victor Babes” University of Medicine and Pharmacy, Department of Microscopic Morphology/ Histology, Angiogenesis Research Center Timisoara Piata Eftimie Murgu no. 2, 300041, Timisoara, Timis, Romania, Phone: 0040256204476 • TUDOR ADELINA MARIA, student ”Victor Babes” University of Medicine and Pharmacy, Department of Microscopic Morphology/ Histology, Angiogenesis Research Center Timisoara Piata Eftimie Murgu no. 2, 300041, Timisoara, Timis, Romania, Phone: 0040256204476 • CRETU OCTAVIAN, MD, PhD, Professor ”Victor Babes” University of Medicine and Pharmacy, Department of Surgery Piata Eftimie Murgu no. 2, 300041, Timisoara, Timis, Romania, Phone: 0040256204476 • NICOLESCU AMALIA, MD, PhD, Teaching Assistant „Vasile Goldis” Western University of Arad, Romania, Department of Intensive Care No.86 Liviu Rebreanu Street, 310045, Arad, Romania, Phone: +40-257-212204 |
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