HomeVolumesJMA, vol. XX, iss. 1, 2017THE ONSET OF BIERMER ANEMIA IN PATIENTS WITH TYPE II DIABETES MELLITUS TREATED WITH METFORMIN

THE ONSET OF BIERMER ANEMIA IN PATIENTS WITH TYPE II DIABETES MELLITUS TREATED WITH METFORMIN

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Article Title: THE ONSET OF BIERMER ANEMIA IN PATIENTS WITH TYPE II DIABETES MELLITUS TREATED WITH METFORMIN
Authors: Alexandru Fica Mircea Onel1, Coralia Adina Cotoraci1, Daniel Răducan3, Nelu-Mihai Trofenciuc1, Verboczki Gabriela Elvira1, Cristina Onel1 , Amorin Remus Popa2
Affiliation: 1″Vasile Goldiş” West University of Arad, Faculty of Medicine
2University of Oradea, Faculty of Medicine
3 “Vasile Goldiş” West University of Arad, Faculty of Pharmacy
Abstract: Management of type 2 diabetes mellitus (DZ2) requires aggressive treatment to achieve the proposed glycemic and cardiovascular goals and to reduce the incidence of risk factors. Metformin, an old and widely accepted first-line agent, stands out not only for its anti-hyperglycaemic properties, but also for its effects outside glycemic control, such as improving endothelial dysfunction, hemostasis and oxidative stress, insulin resistance, redistribution of adipose tissue and the very important role in the vitamin B12 economy and balance within the human body. This retrospective study was performed in Arad County Clinical Emergency Hospital – Hematology Section over 351 patients (aged 18-75 years) diagnosed with type 2 diabetes (termed Lot DZ) admitted to the Arad Hematology Clinic from 2013 to 2015, with a duration of diabetes mellitus of about 1-15 years. The study found that treatment with metformin in patients diagnosed with type II diabetes in combination with cyanobalamin treatment resulted in favorable outcomes, reducing the symptoms of Biermer anemia.
Keywords: Diabetes, Metformin, vitamin B12, therapy, biermer anemia
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*Correspondence: Onel Alexandru Fica Mircea
E-mail: mirceaonel@yahoo.com

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