THE IMPORTANCE OF RIGHT DIAGNOSIS AND TREATMENT OF GASTROINTESTINAL STROMAL TUMORS (GISTs)

THE IMPORTANCE OF RIGHT DIAGNOSIS AND TREATMENT OF GASTROINTESTINAL STROMAL TUMORS (GISTs)

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Title:	THE IMPORTANCE OF RIGHT DIAGNOSIS AND TREATMENT OF GASTROINTESTINAL STROMAL TUMORS (GISTs)
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Article_Title:	THE IMPORTANCE OF RIGHT DIAGNOSIS AND TREATMENT OF GASTROINTESTINAL STROMAL TUMORS (GISTs)
Authors:	Andrei KORODI1 , Eftimie MIUTESCU 2 ,Alexandru DUMNICI 1, Horațiu Sabin PAPIU 1 , Andrei TOMESCU 1
Affiliation:	1 “Vasile Goldiş” Western University of Arad, Romania, Department of Surgery 2 “Vasile Goldiş” Western University of Arad, Romania, Department of Gastroenterology
Abstract:	Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal-derived tumors of the alimentary tract , covering over 1% of gastrointestinal neoplasms. G.I.S.T. are originating from the interstitial cells of Cajal , given the expression of protein CD117, which is the tyrosine kinase receptor known as KIT. Material and method. We studied 11 patients with GIST along last 10 years. Results and discussions. Malignancy is directly proportional to tumor size and mitotic count. The findings on CT frequently include tumors with smooth borders or rounded appearance or an exophytic lobulated lesion. The positive diagnosis is made on immunohistochemical staining. Complete surgical resection remains the mainstay of treatment. Neoadjuvant as well as adjuvant therapy is based on imatinib, which is an oral medication that binds to the thyrosine kinase receptor . Conclusions. GISTs are rare tumors , with difficult diagnosis based on CT, endoscopy and biopsy , very important being the immunohistochemical staining. Excision of these tumors is mandatory.
Keywords:	Gastrointestinal stromal tumors (GISTs), immunohistochemical staining, excision, imatinib, CD117.
References:	Aurora D. Pryor, Theodore N. Pappas and Malcolm Stanley Branch: Gastrointestinal Bleeding: A Practical Approach to Diagnosis and Management Publisher: Springer; 2010 edition (22 Mar 2010) 65-103, 96, 97. Charles J. Yeo MD (Author), Jeffrey B. Matthews MD (Author), David W McFadden MD (Author), John H. Pemberton MD (Author), Jeffrey H. Peters MD (Author): Shackelford’s Surgery of the Alimentary Tract Publisher: Saunders; 7 edition (31 July 2012) 1028-1035 Elisabetta de Lutio di Castelguidone and Antonella Messina: GISTs – Gastrointestinal Stromal Tumors Publisher: Springer; 2011 edition (7 Dec 2010) Y. Kitamura, Markku Miettinen, S. Hirota and Y. Kanakura: Gastrointestinal Stromal Tumor (GIST): From Pathology to Molecular Target Therapy: 53 (Gann Monograph on Cancer Research) Publisher: S Karger AG (23 May 2005)
Read_full_article:	pdf/vol15/iss1-4/2 JMA 2012 A Korodi – THE IMPORTANCE OF RIGH.pdf
Correspondence:	Korodi Dan Andrei, resident 6th year general surgery “Vasile Goldiş” Western University of Arad, Department of Surgery Facultatea de Medicină, Farmacie si Medicină Dentară Adress: Str.Clujului nr.79 310047 Arad Romania Phone : 0040723226580 E-mail: andreikorodi@yahoo.com

	Read full article
Article Title:	THE IMPORTANCE OF RIGHT DIAGNOSIS AND TREATMENT OF GASTROINTESTINAL STROMAL TUMORS (GISTs)
Authors:	Andrei KORODI1 , Eftimie MIUTESCU 2 ,Alexandru DUMNICI 1, Horațiu Sabin PAPIU 1 , Andrei TOMESCU 1
Affiliation:	1 “Vasile Goldiş” Western University of Arad, Romania, Department of Surgery 2 “Vasile Goldiş” Western University of Arad, Romania, Department of Gastroenterology
Abstract:	Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal-derived tumors of the alimentary tract , covering over 1% of gastrointestinal neoplasms. G.I.S.T. are originating from the interstitial cells of Cajal , given the expression of protein CD117, which is the tyrosine kinase receptor known as KIT. Material and method. We studied 11 patients with GIST along last 10 years. Results and discussions. Malignancy is directly proportional to tumor size and mitotic count. The findings on CT frequently include tumors with smooth borders or rounded appearance or an exophytic lobulated lesion. The positive diagnosis is made on immunohistochemical staining. Complete surgical resection remains the mainstay of treatment. Neoadjuvant as well as adjuvant therapy is based on imatinib, which is an oral medication that binds to the thyrosine kinase receptor . Conclusions. GISTs are rare tumors , with difficult diagnosis based on CT, endoscopy and biopsy , very important being the immunohistochemical staining. Excision of these tumors is mandatory.
Keywords:	Gastrointestinal stromal tumors (GISTs), immunohistochemical staining, excision, imatinib, CD117.
References:	Aurora D. Pryor, Theodore N. Pappas and Malcolm Stanley Branch: Gastrointestinal Bleeding: A Practical Approach to Diagnosis and Management Publisher: Springer; 2010 edition (22 Mar 2010) 65-103, 96, 97. Charles J. Yeo MD (Author), Jeffrey B. Matthews MD (Author), David W McFadden MD (Author), John H. Pemberton MD (Author), Jeffrey H. Peters MD (Author): Shackelford’s Surgery of the Alimentary Tract Publisher: Saunders; 7 edition (31 July 2012) 1028-1035 Elisabetta de Lutio di Castelguidone and Antonella Messina: GISTs – Gastrointestinal Stromal Tumors Publisher: Springer; 2011 edition (7 Dec 2010) Y. Kitamura, Markku Miettinen, S. Hirota and Y. Kanakura: Gastrointestinal Stromal Tumor (GIST): From Pathology to Molecular Target Therapy: 53 (Gann Monograph on Cancer Research) Publisher: S Karger AG (23 May 2005)
*Correspondence:	Korodi Dan Andrei, resident 6th year general surgery “Vasile Goldiş” Western University of Arad, Department of Surgery Facultatea de Medicină, Farmacie si Medicină Dentară Adress: Str.Clujului nr.79 310047 Arad Romania Phone : 0040723226580 E-mail: andreikorodi@yahoo.com

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