THE IMPACT FACTORS OF ERECTILE DYSFUNCTION IN MULTIPLE SCLEROSIS PATIENTS

This is an automatically generated default intro template – please do not edit.

	Read full article
Article Title:	THE IMPACT FACTORS OF ERECTILE DYSFUNCTION IN MULTIPLE SCLEROSIS PATIENTS
Authors:	HRENIUC N. CATALIN¹, IOIART IOAN²
Affiliation:	¹Department of Neurology, Western University of Arad „Vasile Goldis”, Romania ²Department of Urology, Western University of Arad „Vasile Goldis”, Romania
Abstract:	Sexual dysfunction (SD) is a common problem, but often underestimated in multiple sclerosis (MS) patients, having a major negative impact on quality of life in patients diagnosed with MS. The purpose of this study is to investigate the nature and prevalence of sexual dysfunction in patients with MS and the analysis of their relationship to various clinical and psychosocial variables. In 37 patients with relapsing remitting multiple sclerosis (41.63 ± 6.052 years), was assessed the ED using the short version of the of the International Index of erectile function (IIEF5). The assessment was made again after 12 months. The data obtained in the study was compared with data from a control group, which consisted of 30 people aged between 40 and 65 years (52.27 ± 8.35). The IIEF5 scores dropped to 16 [median; Q1-Q3 quartiles range (IQR) 12-20] in group 2, from 17 (median, IQR 13-21) in group 1, and are significantly lower compared to the control group (median 22.5 IIEF5; IQR 21-24; p <0.001). Analyzing the IIEF5 scores and EDSS scores in MS patients has shown a strong correlation between these two scores, both on admission (ρ = -0.874, p <0.001) and after 12 months (ρ = -0.879, p <0.001). Although ED is a frequent pathology at multiple sclerosis patients is often underestimated. The ED at MS patients can occur even in the absence of a marked physical disabilities.The sexual dysfunctions present in patients with MS are represented by a complex set of circumstances, associated with several anatomical, physiological, biological, and psychological factors
Keywords:	erectile dysfunction, IIEF5, multiple sclerosis, EDSS score, MSISQ-19
References:	1. DasGupta R., C.J. Fowler, Sexual and urological dysfunction in multiple sclerosis: better understanding and improved therapies, Curr Opin Neurol, 15 (2002), pp. 271–27 2. Demirkiran M., Y. Sarica, S. Uguz, D. Yerdelen, K. Aslan Multiple sclerosis patients with and without sexual dysfunction: are there any differences?, Mult Scler, 12 (2006), pp. 209–214 3. Nortvedt M.W., T. Riise, J. Frugard, J. Mohn, A. Bakke, A.B. Skar, et al., Prevalence of bladder, bowel and sexual problems among multiple sclerosis patients two to five years after diagnosis, Mult Scler, 13 (2007), pp. 106–112 4. Tepavcevic D.K., J. Kostic, I.D. Basuroski, N. Stojsavljevic, T. Pekmezovic, J. Drulovic, The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis, Mult Scler, 14 (2008), pp. 1131–1136 5. Kessler T.M , C.J. Fowler, J.N. Panicker, Sexual dysfunction in multiple sclerosis, Expert Rev Neurother, 9 (2009), pp. 341–35 6. Foley FW, LaRocca NG, Sanders AS, ZemonV. Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. MultScler 2001;7:417–21 7. Zorzon M, R. Zivadinov, A. Bosco, L.M. Bragadin, R. Moretti, L. Bonfigli, et al.Sexual dysfunction in multiple sclerosis: a case-control study. I. Frequency and comparison of groups. Mult Scler, 5 (1999), pp. 418–427 8. Zivadinov r., M. Zorzon, A. Bosco, L.M. Bragadin, R. Moretti, L. Bonfigli, et al. Sexual dysfunction in multiple sclerosis: II. Correlation analysis, Mult Scler, 5 (1999), pp. 428–431 9. Safarinejad M.R. Evaluation of endocrine profile, hypothalamic-pituitary-testis axis and semen quality in multiple sclerosis, J Neuroendocrinol, 20 (2008), pp. 1368–1375 10. Staerman F, P. Guiraud, P. Coeurdacier, D. Menard, G. Edan, B. Lobel, Value of nocturnal penile tumescence and rigidity (NPTR) recording in impotent patients with multiple sclerosis, Int J Impot Res, 8 (1996), pp. 241–245 11. Calabro R.S, R. De Luca, V. Conti-Nibali, S. Reitano, A. Leo, P. Bramanti, Sexual dysfunction in male patients with multiple sclerosis: a need for counseling!Int J Neurosci (2014) 12. DasGupta R, C.J. Fowler, Bladder, bowel and sexual dysfunction in multiple sclerosis: management strategies. Drugs, 63 (2003), pp. 153–166 13.Mattson D, M. Petrie, D.K. Srivastava, M. McDermott, Multiple sclerosis. Sexual dysfunction and its response to medications. Arch Neurol, 52 (1995), pp. 862–868 14. Nortvedt M.W, T. Riise, K.M. Myhr, A.M. Landtblom, A. Bakke, H.I. Nyland, Reduced quality of life among multiple sclerosis patients with sexual disturbance and bladder dysfunction. Mult Scler, 7 (2001), pp. 231–235 15. McCabe M.P,Exacerbation of symptoms among people with multiple sclerosis: impact on sexuality and relationships over time. Arch Sex Behav, 33 (2004), pp. 593–601 16. Cavalla P, V. Rovei, S. Masera, M. Vercellino, M. Massobrio, R. Mutani, et al. Fertility in patients with multiple sclerosis: current knowledge and future perspectives. Neurol Sci, 27 (2006), pp. 231–239 17. Guo Y.N, S.Y. He, H.L. Zhang, J. Wu, Y. Yang, Multiple sclerosis and sexual dysfunction. Asian J Androl, 14 (2012), pp. 530–535 18. Rosen R.C, R.M. Lane, M. Menza, Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol, 19 (1999), pp. 67–85 19. Denys P, M. Mane, P. Azouvi, E. Chartier-Kastler, J.B. Thiebaut, B. Bussel, Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions. Arch Phys Med Rehabil, 79 (1998), pp. 494–496
*Correspondence: