THE ENDOCRINE PSYCHO-SYNDROME IN DYSTHYROIDISM

THE ENDOCRINE PSYCHO-SYNDROME IN DYSTHYROIDISM

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Title:	THE ENDOCRINE PSYCHO-SYNDROME IN DYSTHYROIDISM
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Article_Title:	THE ENDOCRINE PSYCHO-SYNDROME IN DYSTHYROIDISM
Authors:	A. Megieșan
Affiliation:	“Pelican” Clinical Hospital of Oradea
Abstract:	The study aims to prove an obvious link between the increased TSH level and the normal or low FT4 levels and/ or the ATPO (anti-peroxidase antibodies) presence and the pathology of the bipolar or unipolar affective disorders in the context of the initial presence of crude hypothyroidism or clinically expressed and the occurrence of the depression. The gathered data show us the possibility of developing a depression without obvious clinic manifestations (proven only by increased dosages of TSH and normal values of FT4 – which proves in the laboratory of the crude hypothyroidism or of those with certain hypothyroidism – that is increased TSH values and low values of FT4). The achieved results prove without doubt a relation between the thyroid dysfunction and the depression which support the necessity of a double therapeutic approach, both psychiatrical and endocrine.
Keywords:	Crude hypothyroidism, bipolar affective disorder, SSRI inhibitors for re-capturing the serotonin, NaSSA mirtazapine, anti-depressives, TSH, FT4, ATPO
References:	Herneman G, Krenning EP,Argiayyi Jacques: Hypothyroidism: Causes, Mechanisms, Clinical Presentation Diagnosis, Treatment. Thyroid International 1996,3:3-19, published by Merck KgaA Darmstadt Dugbartey AT: Neurocognitive aspects of hypothyroidism Arch Intern Med 1998, 158:1413-18 Hollowell JG, Staehling NW, Flanders WD: Serum TSH, T4 and thyroid antibodies in the United States Population (1988-1994). National Health and Nutrition Examination Survey (NHANES III). J CLIN Endocrinol Metab 2002, 87:489-99 Wiersinga , Wilmar M: Subclinical Thyroidology .Thyroid International 1997, 4:31-36 Esposito S, Prange Jr AJ, Golden RN: The thyroid axis and mood disorders: overview and future perspectives. Psychopharm Bull 1997;33:205-317 Cooper DS, Halpern L, Wood LC, Levin AA, Ridgway EC :L-thyroxin therapy in subclinical hypothyroidism: a double blind placebo-controlled studies. Ann Intern Med 1984, 101:18 Hendrick V: Psychoneuroendocrinology of mood disorders. The hypothalamic pituitary thyroid axis. Psychiatr Clin North Am 1998, 21:277-292
Read_full_article:	pdf/vol18/iss2/11 JMA 2015 – Megiesan – art2.pdf
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Article Title:	THE ENDOCRINE PSYCHO-SYNDROME IN DYSTHYROIDISM
Authors:	A. Megieșan
Affiliation:	“Pelican” Clinical Hospital of Oradea
Abstract:	The study aims to prove an obvious link between the increased TSH level and the normal or low FT4 levels and/ or the ATPO (anti-peroxidase antibodies) presence and the pathology of the bipolar or unipolar affective disorders in the context of the initial presence of crude hypothyroidism or clinically expressed and the occurrence of the depression. The gathered data show us the possibility of developing a depression without obvious clinic manifestations (proven only by increased dosages of TSH and normal values of FT4 – which proves in the laboratory of the crude hypothyroidism or of those with certain hypothyroidism – that is increased TSH values and low values of FT4). The achieved results prove without doubt a relation between the thyroid dysfunction and the depression which support the necessity of a double therapeutic approach, both psychiatrical and endocrine.
Keywords:	Crude hypothyroidism, bipolar affective disorder, SSRI inhibitors for re-capturing the serotonin, NaSSA mirtazapine, anti-depressives, TSH, FT4, ATPO
References:	Herneman G, Krenning EP,Argiayyi Jacques: Hypothyroidism: Causes, Mechanisms, Clinical Presentation Diagnosis, Treatment. Thyroid International 1996,3:3-19, published by Merck KgaA Darmstadt Dugbartey AT: Neurocognitive aspects of hypothyroidism Arch Intern Med 1998, 158:1413-18 Hollowell JG, Staehling NW, Flanders WD: Serum TSH, T4 and thyroid antibodies in the United States Population (1988-1994). National Health and Nutrition Examination Survey (NHANES III). J CLIN Endocrinol Metab 2002, 87:489-99 Wiersinga , Wilmar M: Subclinical Thyroidology .Thyroid International 1997, 4:31-36 Esposito S, Prange Jr AJ, Golden RN: The thyroid axis and mood disorders: overview and future perspectives. Psychopharm Bull 1997;33:205-317 Cooper DS, Halpern L, Wood LC, Levin AA, Ridgway EC :L-thyroxin therapy in subclinical hypothyroidism: a double blind placebo-controlled studies. Ann Intern Med 1984, 101:18 Hendrick V: Psychoneuroendocrinology of mood disorders. The hypothalamic pituitary thyroid axis. Psychiatr Clin North Am 1998, 21:277-292
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