The correlation between cognitive decline and the incidence and the influence of metabolic…

The correlation between cognitive decline and the incidence and the influence of metabolic…

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Article_Title: The correlation between cognitive decline and the incidence and the influence of metabolic syndrome in elderly subjects with mild cognitive decline
Authors: Sanda Maria Deme1, Pavel Dan Nanu1, Catalin Dragos Jianu2, Stefania Kory-Calomfirescu3, Dana Simona Ioncu2
Affiliation: 1 “Vasile Goldis” Western University of Arad, Romania
2 “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
3 “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania
Abstract: Introduction: The leading causes of irreversible cognitive impairment of late life are Alzheimer disease (AD) and vascular cognitive impairment, vascular dementia (VD). Purpose: To evaluate the incidence and the influence of the metabolic syndrome and metabolic syndrome components on a third age population with mild cognitive impairment and no prior history of cognitive decline. Material and method: The subjects included in this study were admitted in the ER and the Neurology Clinic of “Vasile Goldis” Western University of Arad during a period of 4 years, beginning with 2004. 198 subjects qualified the inclusion/exclusion criteria set for this study. Results: Most of the included subjects were men (56.57%). The average age was 68.3 +/- 4.5 years. The incidence of the MetSy in the study group was 39.39. The most significant cognitive decline is associated to the presence of HTA, leukoaraiosis and age with a mean decrease in MMSE score of -4.556, -4.235 and -3.568. Conclusions: Mild cognitive impairment is more frequent and significantly associated to metabolic syndrome and other vascular risk factors.
Keywords: cognitive decline, metabolic syndrome, elderly
References: Gorelick PB, Prevention, in: Bowler JV, Hachinski V., Vascular Cognitive Impairment, Preventable Dementia, New York, NY, Oxford University Press,308–320,2003.
Hachinski V., Vascular dementia: a radical redefinition,Dementia,5,130-132,1994.
Iadecola C., Gorelick P.B., Converging pathogenic mechanisms in vascular and neurodegenerative dementia, Stroke, 34, 335-337, 2003.
Vagnucci AH, Li WW, Alzheimer’s disease and angiogenesis, Lancet, 361, 605-608, 2003.
Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA, Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology, Neurology, 62, 1148-1155, 2004.
Casserly I, Topol E, Convergence of atherosclerosis and Alzheimer’s disease: inflammation, cholesterol, and misfolded proteins, Lancet, 363, 1139-1146, 2004.
Chui H, Vascular dementia, a new beginning, Shifting focus from clinical phenotype to ischemic brain injury, Neurol Clin,18,951-977,2000.
Nussbaum RL, Ellis CE, Alzheimer’s disease and Parkinson’s disease (genomic medicine), N Engl J Med., 348, 1356-1364, 2003.
Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M; for the Women’s Health Initiative Investigators, Estrogen plus progestin and the risk of coronary heart disease, N Engl J Med., 349, 523-534,2003.
Etminan M, Gill S, Samii A, Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer’s disease: systematic review and meta-analysis of observational studies, BMJ, 327, 128, 2003.
Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA, Framingham Stroke Risk Profile and lowered cognitive performance, Stroke 35, pp. 404-409, 2004.
Read_full_article: pdf/vol13/iss3/JMA13-3-10Deme.pdf
Correspondence: Sanda Maria Deme, “Vasile Goldiş” Western University Arad, Faculty of Medicine, Department of Neurology, no. 1 Feleacului St., 310396, Arad, Romania, Tel. +40-(257)-212204, Fax. +40-(257)-212204, email: sandademe@yahoo.com

Read full article
Article Title: The correlation between cognitive decline and the incidence and the influence of metabolic syndrome in elderly subjects with mild cognitive decline
Authors: Sanda Maria Deme1, Pavel Dan Nanu1, Catalin Dragos Jianu2, Stefania Kory-Calomfirescu3, Dana Simona Ioncu2
Affiliation: 1 “Vasile Goldis” Western University of Arad, Romania
2 “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
3 “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania
Abstract: Introduction: The leading causes of irreversible cognitive impairment of late life are Alzheimer disease (AD) and vascular cognitive impairment, vascular dementia (VD). Purpose: To evaluate the incidence and the influence of the metabolic syndrome and metabolic syndrome components on a third age population with mild cognitive impairment and no prior history of cognitive decline. Material and method: The subjects included in this study were admitted in the ER and the Neurology Clinic of “Vasile Goldis” Western University of Arad during a period of 4 years, beginning with 2004. 198 subjects qualified the inclusion/exclusion criteria set for this study. Results: Most of the included subjects were men (56.57%). The average age was 68.3 +/- 4.5 years. The incidence of the MetSy in the study group was 39.39. The most significant cognitive decline is associated to the presence of HTA, leukoaraiosis and age with a mean decrease in MMSE score of -4.556, -4.235 and -3.568. Conclusions: Mild cognitive impairment is more frequent and significantly associated to metabolic syndrome and other vascular risk factors.
Keywords: cognitive decline, metabolic syndrome, elderly
References: Gorelick PB, Prevention, in: Bowler JV, Hachinski V., Vascular Cognitive Impairment, Preventable Dementia, New York, NY, Oxford University Press,308–320,2003.
Hachinski V., Vascular dementia: a radical redefinition,Dementia,5,130-132,1994.
Iadecola C., Gorelick P.B., Converging pathogenic mechanisms in vascular and neurodegenerative dementia, Stroke, 34, 335-337, 2003.
Vagnucci AH, Li WW, Alzheimer’s disease and angiogenesis, Lancet, 361, 605-608, 2003.
Schneider JA, Wilson RS, Bienias JL, Evans DA, Bennett DA, Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology, Neurology, 62, 1148-1155, 2004.
Casserly I, Topol E, Convergence of atherosclerosis and Alzheimer’s disease: inflammation, cholesterol, and misfolded proteins, Lancet, 363, 1139-1146, 2004.
Chui H, Vascular dementia, a new beginning, Shifting focus from clinical phenotype to ischemic brain injury, Neurol Clin,18,951-977,2000.
Nussbaum RL, Ellis CE, Alzheimer’s disease and Parkinson’s disease (genomic medicine), N Engl J Med., 348, 1356-1364, 2003.
Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M; for the Women’s Health Initiative Investigators, Estrogen plus progestin and the risk of coronary heart disease, N Engl J Med., 349, 523-534,2003.
Etminan M, Gill S, Samii A, Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer’s disease: systematic review and meta-analysis of observational studies, BMJ, 327, 128, 2003.
Elias MF, Sullivan LM, D’Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA, Framingham Stroke Risk Profile and lowered cognitive performance, Stroke 35, pp. 404-409, 2004.
*Correspondence: Sanda Maria Deme, “Vasile Goldiş” Western University Arad, Faculty of Medicine, Department of Neurology, no. 1 Feleacului St., 310396, Arad, Romania, Tel. +40-(257)-212204, Fax. +40-(257)-212204, email: sandademe@yahoo.com