SIMULTANEOUS MULTICENTRIC COLORECTAL CARCINOMAS, DIAGNOSIS, THERAPEUTIC OPTIONS, PROGNOSIS CASE REPORT

SIMULTANEOUS MULTICENTRIC COLORECTAL CARCINOMAS, DIAGNOSIS, THERAPEUTIC OPTIONS, PROGNOSIS CASE REPORT

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Title:	SIMULTANEOUS MULTICENTRIC COLORECTAL CARCINOMAS, DIAGNOSIS, THERAPEUTIC OPTIONS, PROGNOSIS CASE REPORT
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Article_Title:	SIMULTANEOUS MULTICENTRIC COLORECTAL CARCINOMAS, DIAGNOSIS, THERAPEUTIC OPTIONS, PROGNOSIS CASE REPORT
Authors:	Alexandru Dumnici 1, Cristian Valan1, Andrei Korodi1 , Gigi Aiordachioaie1, Alex Gaman2, Horatiu Papiu1
Affiliation:	1 ” Vasile Goldis “̋ Western University of Arad, Romania, Department of General Surgery 2 Arad County Hospital, General Surgery Clinic II
Abstract:	Simultaneous multicentric colorectal carcinomas (SMCRC) are rare, but the incidence is increasing significantly lately due to the progress of diagnostic procedures, which are more and more performing. The etiopathogenic and prognostic factors of these tumors are only partially known. Therapist does not have a well-defined protocol, which is why the treatment is strictly personalized depending on the staging of tumors, clinic’s performances and patient options. The role of preoperative imaging is essential in the discovery of multiple and simultaneous cancerous localizations. The golden rule of intraoperative detailed and complete exploration remains valid today. The mirage of discovering a colonic tumor must not distract the attention of the surgical team, which must not forget to control the whole colon and the rectum and , also, the other abdominal organs. A rare case of simultaneous multicentric colorectal carcinomas is presented in the current context of diagnostic and therapeutic possibilities.
Keywords:	colorectal, multicentric , simultaneous, etiopathogenesis, personalized treatment.
References:	1. Jun Yang, Jia Yuan Yuan Peng, Wei Chen :Synchronous Colorectal Cancers : A review of clinical features , Diagnosis, Treatment and Prognosis : DigSurg2011; 28:379-385. 2. Warren S, Gates O : Carcinoma of ceruminous glands. Am J Pathol1941:17;821826.3. 3. Welch J.P Multiple colorectal tumors, An appraisal of natural history and therapeutic options. Am J surg 1981:142;274-280 4. Oya M. Takahashi S, Okuyama T., Yamaguchi M., Ueda Y., Syncrounous colorectal carcinoma : Chinical pathological features and prognosis. Jpn J.clin oncol 2003;33:28-43. 5. Tr.Patrascu, H.Doran, O.Mihalache , D.Degeratu, G.Predescu, Tumori sincrone ale tractului digestiv Chirurgia 105(1):93-96 2016. 6. World cancer report 2014.World Health Organisation.2014.pp.Chapters 5.5 ISBN 9283204298 from Wikipedia. 7. Uneo M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T:Multiple primary cancer: An experience at the Cancer institute hospital ,with special reference to colorectal cancer . Int J Clin Oncol 2003; 8:162-167. 8. Passman MA Pommier RF, Vetto JT: Synchronous colon primaries have the same prognosis as solitary colon cancers.Dis colon rectum 1996;39:329-334. 9. Fukatsu H, Kato J, Nasu J.L, Kavamoto H, Okada H, Yamamoto H, Sakaguchi K, Shiratoni Y:Clinical characteristics of sychronous colorectal cancer ar different according to tumors location Dig Lives Dis 2007;39:40-46 10. Kaiba N Koga S ,Jinnai D:Synchronous and methacronous malignancies of the colon and rectum in Japan with special reference to a coexisting early cancer. Cancer 1984:54;1870-1874 11. Chen HS, Sheen-Chen SM: Synchronous and early methacronous colorectal adenocarcinoma : analysis of prognosis and curent trends .Dis Colon Rectum 2000;43:1093-1099 12. Borda A, Martinez-Penuela JM, Munoz-Navas M, Prieto C , Betes M, Borda F:Synchronous neoplastic lesionsin colorectal cancer. An analisys of possible risk factors favouring presentation. Rev Esp Enferm Dig2008;100:139-145. 13. Mc Arhtur DR, Mehrzod H., Patel R., Dadds J., Pollan A., Karadikar SS, Roy Chandhury S.: CT colonography for synchronous colorectal lesions in pacients with colorectal cancer initial experience. Eur Radiol 2010;20:621-629 14. Achim MP, Holst Andersen LP. Klein M, Chabonova E, Thomsen HS., Rosenberg J:Preoperative evaluation of synchronous colorectal cancer using MR colonography. Acad Radiol 2009;16:790-797
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Article Title:	SIMULTANEOUS MULTICENTRIC COLORECTAL CARCINOMAS, DIAGNOSIS, THERAPEUTIC OPTIONS, PROGNOSIS CASE REPORT
Authors:	Alexandru Dumnici 1, Cristian Valan1, Andrei Korodi1 , Gigi Aiordachioaie1, Alex Gaman2, Horatiu Papiu1
Affiliation:	1 ” Vasile Goldis “̋ Western University of Arad, Romania, Department of General Surgery 2 Arad County Hospital, General Surgery Clinic II
Abstract:	Simultaneous multicentric colorectal carcinomas (SMCRC) are rare, but the incidence is increasing significantly lately due to the progress of diagnostic procedures, which are more and more performing. The etiopathogenic and prognostic factors of these tumors are only partially known. Therapist does not have a well-defined protocol, which is why the treatment is strictly personalized depending on the staging of tumors, clinic’s performances and patient options. The role of preoperative imaging is essential in the discovery of multiple and simultaneous cancerous localizations. The golden rule of intraoperative detailed and complete exploration remains valid today. The mirage of discovering a colonic tumor must not distract the attention of the surgical team, which must not forget to control the whole colon and the rectum and , also, the other abdominal organs. A rare case of simultaneous multicentric colorectal carcinomas is presented in the current context of diagnostic and therapeutic possibilities.
Keywords:	colorectal, multicentric , simultaneous, etiopathogenesis, personalized treatment.
References:	1. Jun Yang, Jia Yuan Yuan Peng, Wei Chen :Synchronous Colorectal Cancers : A review of clinical features , Diagnosis, Treatment and Prognosis : DigSurg2011; 28:379-385. 2. Warren S, Gates O : Carcinoma of ceruminous glands. Am J Pathol1941:17;821826.3. 3. Welch J.P Multiple colorectal tumors, An appraisal of natural history and therapeutic options. Am J surg 1981:142;274-280 4. Oya M. Takahashi S, Okuyama T., Yamaguchi M., Ueda Y., Syncrounous colorectal carcinoma : Chinical pathological features and prognosis. Jpn J.clin oncol 2003;33:28-43. 5. Tr.Patrascu, H.Doran, O.Mihalache , D.Degeratu, G.Predescu, Tumori sincrone ale tractului digestiv Chirurgia 105(1):93-96 2016. 6. World cancer report 2014.World Health Organisation.2014.pp.Chapters 5.5 ISBN 9283204298 from Wikipedia. 7. Uneo M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T:Multiple primary cancer: An experience at the Cancer institute hospital ,with special reference to colorectal cancer . Int J Clin Oncol 2003; 8:162-167. 8. Passman MA Pommier RF, Vetto JT: Synchronous colon primaries have the same prognosis as solitary colon cancers.Dis colon rectum 1996;39:329-334. 9. Fukatsu H, Kato J, Nasu J.L, Kavamoto H, Okada H, Yamamoto H, Sakaguchi K, Shiratoni Y:Clinical characteristics of sychronous colorectal cancer ar different according to tumors location Dig Lives Dis 2007;39:40-46 10. Kaiba N Koga S ,Jinnai D:Synchronous and methacronous malignancies of the colon and rectum in Japan with special reference to a coexisting early cancer. Cancer 1984:54;1870-1874 11. Chen HS, Sheen-Chen SM: Synchronous and early methacronous colorectal adenocarcinoma : analysis of prognosis and curent trends .Dis Colon Rectum 2000;43:1093-1099 12. Borda A, Martinez-Penuela JM, Munoz-Navas M, Prieto C , Betes M, Borda F:Synchronous neoplastic lesionsin colorectal cancer. An analisys of possible risk factors favouring presentation. Rev Esp Enferm Dig2008;100:139-145. 13. Mc Arhtur DR, Mehrzod H., Patel R., Dadds J., Pollan A., Karadikar SS, Roy Chandhury S.: CT colonography for synchronous colorectal lesions in pacients with colorectal cancer initial experience. Eur Radiol 2010;20:621-629 14. Achim MP, Holst Andersen LP. Klein M, Chabonova E, Thomsen HS., Rosenberg J:Preoperative evaluation of synchronous colorectal cancer using MR colonography. Acad Radiol 2009;16:790-797
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