PREVALENCE OF PROSTATE DISEASES IN A COHORT STUDY CONDUCTED IN RADIOACTIVE CONTAMINATED AREAS IN ARAD COUNTY
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| Article Title: | PREVALENCE OF PROSTATE DISEASES IN A COHORT STUDY CONDUCTED IN RADIOACTIVE CONTAMINATED AREAS IN ARAD COUNTY |
| Authors: | Imola Miklos1,2, Alin Greluș1,2, Dragoș Botezatu1,2, Horia Mureșanu1, Adrian Crișan3, Paul Deme3, Ioan Ioiart1 |
| Affiliation: | 1Urology Clinic, Arad County Emergency Hospital, Romania 2”Vasile Goldiș” Western University of Arad, Institute of Life Science, Romania 3”Vasile Goldiș” Western University of Arad, Faculty of Medicine |
| Abstract: | The most frequent prostate diseases are: prostatitis in young men, benign prostatic hyperplasia in men over 50 years, and prostate cancer which has long been the disease of elderly, but in recent years has shown increasing frequency in men under 60 years. This study is an observational-prospective study, which aims to appreciate the correlations between the characteristics of Arad County with the occurrence of prostate diseases. We selected 276 patients as follow: 181 patients with benign prostatic hyperplasia, 19 healthy subjects as a control group, 12 patients with prostatic premalignant lesions, and 64 prostate cancer patients. In the last few years Arad County was the leader in cancer incidence with 3.6-3.8 cases per 100 inhabitants. In some areas of Arad County soil and waters are rich in arsenic and uranium and additionally the major concern is in animal farms. The residues from zootechnics can affect the quality of soil and water. These toxic substances can lead to genetic changes, like DNA hypermethylation, that cause cancer illnesses. We observed, that many patients diagnosed with prostate neoplasia come from the high risk areas. |
| Keywords: | benign prostatic hypertrophy, BPH prevalence, prostate cancer, PC prevalence, ASAP, HG-PIN |
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| *Correspondence: | Miklos Imola Adress: Urology Clinic, Arad County Emergency Hospital, Str. Andrenyi Karoly, Nr. 2 – 4, Arad, 310037, Romania, Tel. +40-0773342983, e-mail: miklosimola@gmail.com |
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