MODIFICATIONS IN VALUES OF GASTRIN SERUM AND CARBONIC ANHYDRASE AFTER THERAPY TO ERADICATE THE HELICOBACTER PYLORI IN DUODENAL ULCER PATIENTS

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Article Title:	MODIFICATIONS IN VALUES OF GASTRIN SERUM AND CARBONIC ANHYDRASE AFTER THERAPY TO ERADICATE THE HELICOBACTER PYLORI IN DUODENAL ULCER PATIENTS
Authors:	CLAUDIA ANCA DUME 1*, IOAN PUSCAS2, MARCELA COLTAU2
Affiliation:	1 Regional Gastroenterology and Hepatology Institute “Prof. O. Fodor” Cluj Napoca; 2 Municipal Hospital “Prof. Dr. Ioan Puscas” Simleu Silvaniei
Abstract:	Many researchers have suggested that measuring the levels of gastrin and pepsinogen during the treatment to eradicate H. pylori infection may be useful to assess whether the treatment is effective or not. The gastrin which is a key- enzyme in modulating gastric acid secretion is also a direct activator of carbonic anhydrase (CA). In our work we have studied the effect of treatment to eradicate H. pylori infection on the levels of serum gastrin and carbonic anhydrase IV in the gastric mucosa, in the case of two groups of patients with UD and positive H. pylori diagnostics who were treated by means of triple therapy, and respectively quadruple therapy for 10 days. Endoscopy with biopsy sampling was performed in the case of all patients. The study results prove the implication of isoenzyme CA IV of the gastric mucosa and the gastrin in the action of therapy mechanisms to eradicate H. pylori infection. Following the treatment to eradicate the H. pylori infection one reveals a decrease of CA IV gastric activity by 64% in the Group no. 1 patients, and 78% in the Group no. 2 patients, while the levels of serum in gastrin decrease by 58% in Group no. 1 and by 69% in group no.2, respectively.
Keywords:	Helicobacter pylori, Carbonic anhydrase, Duodenal ulcer, Gastrin
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