Metabolic bone assessment in patients with inflammatory bowel disease
| Abstract Title: | Metabolic bone assessment in patients with inflammatory bowel disease |
| Authors: | Loredana Marian¹, Mioara Banciu², Christian Banciu¹ |
| Affiliation: | 1University of Medicine and Pharmacy "Victor Babes" Timisoara, Romania 2Western University "Vasile Goldis" Arad, Romania |
| Abstract text: | BACKGROUND: patients with Crohn’s disease and ulcerative colitis are at risk for bone demineralization. To study the metabolic bone status of these patients, a cross-sectional study was conducted. METHODS: 28 patients with Crohn’s disease and 34 patients with ulcerative colitis underwent clinical,dietary, and spine radiological assessments. Bone metabolism was assessed by measuring serum levels of calcium, phosphate, parathyroid hormone, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, and osteocalcin. Lumbar and femoral neck bone mineral densities were measured by dual energy X-ray absorptiometry (DEXA). RESULTS: Pateints with Crohn’s disease: serum osteocalcin level was decreased in 10 patients (35,7%), 2 of whom had never undergone steroid therapy. The other biochemical markers of bone metabolism were in the normal range.13 patients (46,4%) had osteopenia, and 2 patients (7,14%) had vertebral crush fractures. No patient had clinical or biological signs of osteomalacia. 15 patients (53,57%) have decreased bone density, 2 patients (13,33%) not received steroids. Patients with ulcerative colitis: serum osteocalcin level was decreased in 3 patients (8,82%), all patients received steroid therapy. The other biochemical markers of bone metabolism were in the normal range.5 patients (14,7%) had osteopenia, and 2 patients (5,88%) had vertebral crush fractures. 3 patients (8,82%) have decreased bone density, all patients received steroids. CONCLUSION: The results suggest that bone turnover in Crohn’s disease is characterized by low bone formation in the presence of normal levels of calcium-regulating hormones. Analysis of bone density (DEXA) showed a significant correlation with age, cumulative corticosteroid doses, sedimentation rate, and osteocalcin level It is a direct effect of circulating proinflammatory cytokines on bone osteoclast activity. Receive frequent courses of steroids decreased bone density.Patients with ulcerative colitis have low increased risk of bone demineralization. |
| Keywords: | inflammatory bowel diseases, bone density, steroids |
| Presentation type: | Poster |
| Correspondence: | timisoara str astrilor nr 18, ap 17 |
| Email: | loredanamarian@hotmail.com |
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