HomeVolumesJMA, vol. XVIII, iss. 2, 2015Expression D2-40 in head and neck squamocellular carcinoma (HNSCC)

Expression D2-40 in head and neck squamocellular carcinoma (HNSCC)

Expression D2-40 in head and neck squamocellular carcinoma (HNSCC)

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Title: Expression D2-40 in head and neck squamocellular carcinoma (HNSCC)
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Article_Title: Expression D2-40 in head and neck squamocellular carcinoma (HNSCC)
Authors: Elisabeta Maria Vasca1, Ioana Lile1, Domenico Napolitano2, Ricciardiello Filippo3, Tuturici Liviu1 ,Virgil Vasca1
Affiliation: 1 Faculty of Medicine, Pharmacy and Dental Medicine, ’’Vasile Goldis” Western University Arad, Romania
2 Divisione ORL A.O.R.N. Cardarelli Napoli, Italia
3Clinica ORL Universita Federico II, Napoli, Italia
Abstract: The D2-40 monoclonal antibody identifies a sialoglycoprotein of kDa that is present in different tissues including the male fetus gonads and the testicular germ cells tumors. It has been demonstrated that D2-40 is expressed in the lymphatic endothelium and it is absent in the vascular endothelium. (17)
In the normal human adult tissue it has been observed, in most of the parenchymatous organs, that the little vascular spaces contain positive lymphatic vessels for D2-40. (13). The number of these vessels varies in different organs.(16). Therefore, they are rare in the spleen (around the central artery and in the capsule), liver (in the port spaces and capsule), kidneys and hematogenous bone marrow. (5) . At the level of the lungs they are usually observed around veins, arterioles, bronchioles but are rare or even absent in the alveolar wall. (10).
Keywords: sialoglycoprotein,squamocellular carcinoma,endogenous peroxidase
References: 1. Greenlee RT, Murray T, Bolden S, Wingo PA (2000). Cancer statistics 2000. CA Cancer J Clin, 50(1):7–33
2. Gasco M, Crook T (2003). The p53 network in head and neck cancer. Oral Oncol, 39: 222–231.
3. Guney E, Yigitbasi OG (2004). Functional surgical approach to the level I for staging early carcinoma of the lower lip. Otolaryngol Head Neck Surg, 131:503–8.
4. Health and Welfare Statistics Association (2005). Journal of Health and Welfare Statistics. Health and Welfare Statistics Association: Tokyo
5. Hansen T, Katenkamp K, Bittinger F, Kirkpatrick CJ and Katenkamp D: D2-40 labeling in lymphangiomyoma/ lymphangiomyomatosis of the soft tissue: further evidence of lymphangiogenic tumor histogenesis. Virchows Arch 450: 449-453, 2007.
6. H. Schipper, U.H. Frixen, J. Behrens, A. Unger, K. Jahnke, W. Birchmeier E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis Cancer Res, 51 (23 Pt 1) (1991), pp. 6328–6337
7. Kademani D (2007). Oral cancer. Mayo Clin Proc, 82: 878– 887.
8. Kalyankrishna S, Grandis JR., Epidermal growth factor receptor biology in head and neck cancer, J Clin Oncol. 2006; 24(17):2666-2672.
9. Kimura N and Kimura I: Podoplanin as a marker for mesothelioma. Pathol Int 55: 83-86, 2005.
10. Llewellyn CD, Johnson NW, Warnakulasuriya KA (2001). Risk factors for squamous cell carcinoma of the oral cavity in young people—a comprehensive literature review. Oral Oncol, 37(5):401–18.
11. Lin JY, Li XY, Dong P et al. Prognostic value of lymphangiogenesis in supraglottic laryngeal carcinoma. J Laringol Otol 2011, 125: 945-500
12. Margaritescu C, Raica M, Pirici D, Simionescu C et al. Podoplanin expression in tumor-free resection margins of oral squamous cell carcinomas: an immunohistochemical andfractal analysis study. Histol Histopathol, 2010, 25: 701-711.
13. O-Charoenrat P, Rhys-Evans PH, Eccles S (2001) Characterization of ten newly-derived human head and neck squamous carcinoma cell lines with special reference to c-erbB proto-oncogene expression. Anticancer Res, 21:1953–1963.
14. Okura M, Harada T, Iida S, Aikawa T, Kogo M (2006). Metastasis to the submandibular gland in oral cavity carcinoma. Oral Oncology EXTRA, 42:308–310.
15. Schimming R, Reusch P, Kuschnierz J, Schmelzeisen R (2004). Angiogenic factors in squamous cell carcinoma of the oral cavity: do they have prognostic relevance? J Cran Max fac Surg. 32:176–181.
16. American Cancer Society (2007). Cancer Facts and Figures 2007. American Cancer Society: Atlanta.
17. Arellano-Garcia ME, Hu S, Wang J, Henson B, Zhou H, Chia D, Wong DT (2008). Multiplexed immunobead-based assay for detection of oral cancer protein biomarkers in saliva. Oral Diseases, 14:705–71
Read_full_article: pdf/vol18/iss2/8 JMA 2015 – Vasca – articol 3 bdi  finalaz.pdf
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Article Title: Expression D2-40 in head and neck squamocellular carcinoma (HNSCC)
Authors: Elisabeta Maria Vasca1, Ioana Lile1, Domenico Napolitano2, Ricciardiello Filippo3, Tuturici Liviu1 ,Virgil Vasca1
Affiliation: 1 Faculty of Medicine, Pharmacy and Dental Medicine, ’’Vasile Goldis” Western University Arad, Romania
2 Divisione ORL A.O.R.N. Cardarelli Napoli, Italia
3Clinica ORL Universita Federico II, Napoli, Italia
Abstract: The D2-40 monoclonal antibody identifies a sialoglycoprotein of kDa that is present in different tissues including the male fetus gonads and the testicular germ cells tumors. It has been demonstrated that D2-40 is expressed in the lymphatic endothelium and it is absent in the vascular endothelium. (17)
In the normal human adult tissue it has been observed, in most of the parenchymatous organs, that the little vascular spaces contain positive lymphatic vessels for D2-40. (13). The number of these vessels varies in different organs.(16). Therefore, they are rare in the spleen (around the central artery and in the capsule), liver (in the port spaces and capsule), kidneys and hematogenous bone marrow. (5) . At the level of the lungs they are usually observed around veins, arterioles, bronchioles but are rare or even absent in the alveolar wall. (10).
Keywords: sialoglycoprotein,squamocellular carcinoma,endogenous peroxidase
References: 1. Greenlee RT, Murray T, Bolden S, Wingo PA (2000). Cancer statistics 2000. CA Cancer J Clin, 50(1):7–33
2. Gasco M, Crook T (2003). The p53 network in head and neck cancer. Oral Oncol, 39: 222–231.
3. Guney E, Yigitbasi OG (2004). Functional surgical approach to the level I for staging early carcinoma of the lower lip. Otolaryngol Head Neck Surg, 131:503–8.
4. Health and Welfare Statistics Association (2005). Journal of Health and Welfare Statistics. Health and Welfare Statistics Association: Tokyo
5. Hansen T, Katenkamp K, Bittinger F, Kirkpatrick CJ and Katenkamp D: D2-40 labeling in lymphangiomyoma/ lymphangiomyomatosis of the soft tissue: further evidence of lymphangiogenic tumor histogenesis. Virchows Arch 450: 449-453, 2007.
6. H. Schipper, U.H. Frixen, J. Behrens, A. Unger, K. Jahnke, W. Birchmeier E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis Cancer Res, 51 (23 Pt 1) (1991), pp. 6328–6337
7. Kademani D (2007). Oral cancer. Mayo Clin Proc, 82: 878– 887.
8. Kalyankrishna S, Grandis JR., Epidermal growth factor receptor biology in head and neck cancer, J Clin Oncol. 2006; 24(17):2666-2672.
9. Kimura N and Kimura I: Podoplanin as a marker for mesothelioma. Pathol Int 55: 83-86, 2005.
10. Llewellyn CD, Johnson NW, Warnakulasuriya KA (2001). Risk factors for squamous cell carcinoma of the oral cavity in young people—a comprehensive literature review. Oral Oncol, 37(5):401–18.
11. Lin JY, Li XY, Dong P et al. Prognostic value of lymphangiogenesis in supraglottic laryngeal carcinoma. J Laringol Otol 2011, 125: 945-500
12. Margaritescu C, Raica M, Pirici D, Simionescu C et al. Podoplanin expression in tumor-free resection margins of oral squamous cell carcinomas: an immunohistochemical andfractal analysis study. Histol Histopathol, 2010, 25: 701-711.
13. O-Charoenrat P, Rhys-Evans PH, Eccles S (2001) Characterization of ten newly-derived human head and neck squamous carcinoma cell lines with special reference to c-erbB proto-oncogene expression. Anticancer Res, 21:1953–1963.
14. Okura M, Harada T, Iida S, Aikawa T, Kogo M (2006). Metastasis to the submandibular gland in oral cavity carcinoma. Oral Oncology EXTRA, 42:308–310.
15. Schimming R, Reusch P, Kuschnierz J, Schmelzeisen R (2004). Angiogenic factors in squamous cell carcinoma of the oral cavity: do they have prognostic relevance? J Cran Max fac Surg. 32:176–181.
16. American Cancer Society (2007). Cancer Facts and Figures 2007. American Cancer Society: Atlanta.
17. Arellano-Garcia ME, Hu S, Wang J, Henson B, Zhou H, Chia D, Wong DT (2008). Multiplexed immunobead-based assay for detection of oral cancer protein biomarkers in saliva. Oral Diseases, 14:705–71
*Correspondence:

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