CHARACTERIZATION OF INCLUSION COMPLEXES FORMED BY 4-METHYLBENZYLIDENE CAMPHOR WITH β – CYCLODEXTRIN, HYDROXYPROPYL – β – CYCLODEXTRIN AND HYDROXYPROPYL – α – CYCLODEXTRIN IN 1:2 MOLAR RATIO

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Article Title:	CHARACTERIZATION OF INCLUSION COMPLEXES FORMED BY 4-METHYLBENZYLIDENE CAMPHOR WITH β – CYCLODEXTRIN, HYDROXYPROPYL – β – CYCLODEXTRIN AND HYDROXYPROPYL – α – CYCLODEXTRIN IN 1:2 MOLAR RATIO
Authors:	RALUCA SBORA¹, EMMA ADRIANA BUDURA²*, GEORGE MIHAI NIŢULESCU³, TEODORA BALACI², DUMITRU LUPULEASA²
Affiliation:	University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania ¹ PhD Student, Pharmaceutical Technology Department ² Pharmaceutical Technology Department ³ Pharmaceutical Chemistry Department
Abstract:	The aim of the present study was to confirm the formation of inclusion complexes between 4-Methylbenzylidene camphor and beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and hydroxypropyl-alfa-cyclodextrin, using lyophilization technique. The inclusion complexes were subjected to physicochemical characterizations in comparison with the simple physical mixtures prepared in the same 1:2 (4-Methylbenzylidene camphor : cyclodextrin) molar ratio. The complexes were evaluated by the scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). The inclusion complexes between 4-Methylbenzylidene camphor and beta-cyclodextrins, in 1:2 molar ratio, found better in all the studied parameters in comparison with the complexes prepared with alfa-cyclodextrin, probably due to the 4-Methylbenzylidene camphor molecule size which fits better in beta-cyclodextrins than in alfa-cyclodextrins cavity.
Keywords:	4-Methylbenzylidene camphor, beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin, hydroxypropyl-alfa-cyclodextrin, inclusion complex, lyophilization.
References:	Budura Emma Adriana, Dumitru Lupuleasa, Corina Aramă, Mihai Niţulescu, Teodora Balaci, Preparation and characterization of inclusion complexes formed between simvastatin and hydroxypropyl-β-cyclodextrin, Farmacia, 2011: vol. 59, 4 : 512 – 530 Budura Emma Adriana, Dumitru Lupuleasa, Corina Aramă, Mihai Niţulescu, Victoria Hîrjău, Influence of the method of preparation on physicochemical characteristics of 1:1 simvastatin – β-cyclodextrin inclusion complex, Studia Universitatis „Vasile Goldiş”, Seria Ştiinţele Vieţii, 2011: vol. 21, 3 : 469-477 Loftsson T., Brewster M., Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci., 85, 1017–1025, 1996. Loftsson T., and Brewster M., Cyclodextrins as pharmaceutical solubilizers, Adv. Drug Deliver. Rev., 59, 645–666, 2007.
*Correspondence:	Corresponding author: Emma Adriana Budura, University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Pharmaceutical Technology Department, No. 6 Traian Vuia St., 020956, Bucharest, Romania, Tel. +40-(21)- 3180740, email: emmacretu@aim.com