| Abstract text: |
Objectives: The authors studied the antibiosensitivity versus resistance models in Salmonella diarrhoea of children from the western part of the country. Based on these models they aimed to create a local guide. Methods: The group consisted of 155 Salmonella strains, isolated from children with acute diarrhoea. The children were admitted in the Infectious Diseases Clinic of Arad and Timisoara during a period of 5 years, from July 2004 to July 2009. The retrospective study used clinical data. The diffusimetric antibiotic test was performed according to the existing standards at the moment. The antibacterial drugs most frequently used in the antibiotic sensitivity testing were selected: Ampicillin, Ampicillin + Sulbactam, Amoxicillin + Clavulanic Acid, Cephalosporins, Gentamicin, Colimycin, Chloramphenicol, Tetracycline, Co-trimoxazole, Nalidixic Acid, Fluoroquinolones and Nitrofurantoin. Results: The Salmonella strains developed a high sensitivity of 91.6% for Fluoroquinolones and a medium sensitivity of 40.6% for Cephalosporins. Furthermore, an important decrease of sensitivity was noticed for Ampicillin (0,6 %), Tetracycline (1,3 %), Colimycin (27,1%) and Co-trimoxazole (31 %). For our group, the following values of antibiotic resistance of Shigella were obtained: 53.1% for Ampicillin, 38,7 % for Co-trimoxazole, 32,3 % for Tetracycline and 31 % for Chloramphenicol. Conclusions: 1. The Fluoroquinolones have the maximum therapeutic benefit; 2. It is necessary to stop using the antibiotics which induce high resistance (Ampicillin, Co-trimoxazole, Tetracycline and Chloramphenicol); 3. The increase of the antibiotic resistance of the Shigella strains in the West of the country is an alarming phenomenon. |
