ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC IMMUNOHISTOCHEMICAL MARKERS

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Article Title:	ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC IMMUNOHISTOCHEMICAL MARKERS
Authors:	ADINA CIURSAȘ*1, T.T.MAGHIAR1, M. PUȘCAȘIU1´2, GABRIELA MUȚIU1, P DEME3
Affiliation:	University of Oradea, Medicine and Pharmacy Faculty, Department of Morphological Sciences1, Pelican County Hospithal of Oradea, Clinical Service of Pathology2 Western University of Vasile Goldis, Arad, Medicine, Dental Medicine and Pharmacy Faculty, Department of General Medicine, Anatomy3
Abstract:	The aim of this study was to use a pannel of antibody/ immunohistochimical markers four lung adenocarcinoma such as Ck 7, Ck 20, TTF – 1,and CD – 15, CEA in differentiating primary from metastatic lung adenocarcinoma. The immunohistochemical markers should always be used in conjunction with the clinical presentation, distribution of the lesions, and the morphology. Have been under study 292 patients with lung carcinoma and in 86 ( 29,45 %).cases we foud adenocarcinoma. On these cases we use a pannel of immunohistochimical markers: Ck 7, Ck 20, TTF- 1, and CD – 15, CEA. Of the 86 lung adenocarcinoma specimens there were 40 primary lung adenocarcinomas, 16 metastatic adenocarcinomas from breast and 30 metastatic adenocarcinomas from colon. We have found that 70% of primary lung adenocarcinomas expressed TTF – 1, whereas all nonpulmonary adenocarcinomas lacked TTF – 1 staining. A combination of TTF – 1+/ Ck 7 +/ Ck 20 –/ was highly significantly associated with primary adenocarcinoma of lung. A combination of TTF – 1 –/ Ck 7 –/ Ck 20 +/ was highly significantly associated with adenocarcinoma of gastrointestinal origin. Our study has confirmed that expression of Ck 7 , Ck 20, TTF – 1 and CD – 15, CEA are useful immunohistochemical markers for diagnosis of lung tumors and for differential diagnosis of primary lung adenocarcinomas from metastatic lung adenocarcinomas .Application of this panel of antibodies might be expected to increase the accuracy of diagnosis.
Keywords:	lung carcinoma, adenocarcinoma,: Ck 7, Ck 20, TTF – 1, CD – 15, CEA
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*Correspondence:	Adina Ciursaș* M.D. – univ. assistent on Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University Oradea, street December 1, Oradea, Romania Adina Ciursas: street Călugăreni nr. 8, bl.C2, ap. 40, Oradea Romania mobile phone: 0728 003 426, e – mail: adina.ciursas@gmail.com, Pelican County Hospital of Oradea, Clinical Service of Pathology, Corneliu Coposu street nr.2, phone:0259 422078 Oradea, Romania