HomeVolumesJMA, vol. XXI, iss. 3, 2018INFLUENZA ANTIVIRAL DRUG THERAPY – AN ACTUAL REWIEW

INFLUENZA ANTIVIRAL DRUG THERAPY – AN ACTUAL REWIEW

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Article Title: INFLUENZA ANTIVIRAL DRUG THERAPY – AN ACTUAL REWIEW
Authors: Lucian Negruțiu1, Daniela T. Marți1, Alexandru Fica Mircea Onel1
Affiliation: 1 “Vasile Goldiș” Western University of Arad, Faculty of Medicine
Abstract: Antiviral resistance means that a virus has changed in such a way that antiviral drugs are less effective or not effective at all in treating or preventing illnesses with that virus. In the last years Influenza viruses can become resistant to influenza antiviral drugs by some molecular mechanisms.In this our work we present a new data regarding: this antiviral drug-resistance of influenza viruses, some mehanisms of this resistance, the new techniques utilised for identification and monitoring of the mechanisms of this resistance and the most newest data obtained by the recent trials realised with a a single dose of Baloxavir marboxil, a first-in-class drug that inhibits a viral protein essential for influenza replication, wich significantly reduced the duration of flu symptoms, duration of fever, length of time of viral shedding, and levels of virus in the nose and throat, compared with placebo or oseltamivir among otherwise healthy people with the flu in three randomized controlled trials.
Keywords: influenza virus, virus resistance, antiviral therapy, the news drugs anti influenza viruses.
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