HUMAN PARAOXONASE 1 – PARACLINICAL MARKER WITH CLINICAL APPLICATION IN THE PREVENTION OF ACUTE CARDIOVASCULAR EVENTS
July 10, 2019
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| Article Title: | HUMAN PARAOXONASE 1 – PARACLINICAL MARKER WITH CLINICAL APPLICATION IN THE PREVENTION OF ACUTE CARDIOVASCULAR EVENTS |
| Authors: | Camelia Ciacli*1, Calin Popa2, Maria Puschita1 |
| Affiliation: | 1 Faculty of General Medicine, Pharmacy and Dental Medicine from „Vasile Goldis” Western University of Arad (Romania); 2 Institute of Cardiovascular Medicine Timisoara (Romania) |
| Abstract: | Paraoxonases are a group of enzymes consisting of three sub-types that were originally discovered for their involvement in the hydrolysis of organophosphatases. Objectives of our study included determination of human paraoxonase 1 (PON1) values at the patients with the highest risk of cardiovascular disease and correlation of the results with the markers of atherosclerosis. We selected a total of 120 hypertensive without chronic treatment; group II (H2) consisting of 30 subjects diagnosed with hypertension, impaired glucose tolerance, obesity (metabolic syndrome); group III (H3) also included 30 patients with hypertension and type II diabetes; group IV (H4) included 30 patients hypertensive with type II diabetes and renal disorders. The control group included 25 clinically healthy subjects. For estimation of the immediately atherogenic risk, atherogenic index of plasma (AIP) is more sensitive to changes in lipid fractions values. Determining the PON1 can, however, estimate the long-term risk of developing cardiovascular diseases. PON1 value is more accurate than AIP for estimating cardiovascular risk, even if PON1 values may be influenced by many factor it may indicate accurately the risk of cardiovascular disease. |
| Keywords: | paraoxonases – atherosclerosis – hypertension – diabetes – obesity – acute cardiovascular events |
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| *Correspondence: | Ciacli Camelia M.D, PhD „Vasile Goldis” Western University of Arad, Tel: +40744635081, e-mail: cciacli@yahoo.com |
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