THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS

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Article Title:	THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS
Authors:	AMALIA NICOLESCU 1, TEODORA OLARIU2
Affiliation:	1 Department of Intensive Care, „Vasile Goldis” Western University of Arad, Romania, 2 Department of Intensive Care, „Vasile Goldis” Western University of Arad, Romania
Abstract:	Lung cancer (PBC) frequency increased alarmingly in the last decades, especially in economically developed countries. The lymphatic microvascular density can be one of the important factors for prognosis in patients with lung carcinomas. The aim of this study was to analysed the D2-40 and VEGF-C expression in tumor cells and lymphatic vessels in the lung squamous cell carcinoma. Our study included a total of 27 cases. The immunoexpression of VEGF-C and D2-40 was evaluated according to the following score: 0 (0% positive cells), 1 (<10% positive cells), 2 (10-30% positive cells) and 3 (> 30% positive cells). VEGF-C score ranged from 0 to 3. The score 0 was found in 7.40% of cases, score 1 in 14.81%, score 2 in 25.92% and score 3 in 51.85% of cases. The lung squamous cell lung carcinomas showed a positive D2-40 lymphatic vessel density higher in the peritumoral comparatively with the intratumoral area. They may contribute to a better understanding of lung cancer biology and individualised therapies.
Keywords:	lung squamous cell carcinoma, D2-40, VEGF-C
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*Correspondence:	Amalia Nicolescu, Western University of Arad, Romania, Department of Intensive Care, Piata Mihai Viteazu, nr. 7-8, tel: (004)0257/257080’, e-mail: birauamalia@yahoo.com