The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction

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Article Title:	The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction
Authors:	Corina Zorila1,Liana Mos1, Elena Magopat2, Eva Mera3
Affiliation:	1.Western University “V. Goldis” Arad, 2.Clinical County Emergency Hospital Arad,2d Internal Medicine Clinic, 3.S.C.Clinical Laboratory SRL. Arad, Romania
Abstract:	The theory of aging by free radicals agree that age is the the consequence of accumulation of lesions induced by free radicals. We use indirect measurement of lipidperoxidation, which is a measure of the reaction products of free radical damage to the lipid substrate, mainly consisting of membrane polyunsaturated fatty acids. Low plasma levels of Vitamin E has been associated with a risk factor of 2.6 times higher early coronary heart disease. Material and methods. We studied a group of 33 patients with cardiovascular disease and/or hypertension (Group I) of atherosclerotic etiology. We administered 2 x 600 alpha-tocopherol mg /day (Vitamin E) for 7 days in capsules. In order to determine the extension of lipoperoxidation we have determined ATB-reactive substances by the method of Satoh in peripheral venous blood, prior to administration of vitamin E and 7 days after treatment. We compared this group (Group I), with another group of patients with symptomatic ischemic heart disease (Group II) without nutritional supplementation. Results.Baseline there is a average level of substance ATB – reactive similar in the two groups, but significantly lower in Group I after nutritional supplementation with alpha-tocopherol. Conclusions. Alpha-tocopherol supplementation in patients with cardiovascular disease, over 60 years, revealed a significant decrease in lipid peroxidation, with protective effect on endothelial dysfunction
Keywords:	aging, lipidperoxidation, vitamin E
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