ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC IMMUNOHISTOCHEMICAL MARKERS


ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC IMMUNOHISTOCHEMICAL MARKERS

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Title: ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC IMMUNOHISTOCHEMICAL MARKERS
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Article_Title: ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC
IMMUNOHISTOCHEMICAL MARKERS
Authors: ADINA CIURSAȘ*1, T.T.MAGHIAR1, M. PUȘCAȘIU1´2, GABRIELA MUȚIU1, P DEME3
Affiliation: University of Oradea, Medicine and Pharmacy Faculty, Department of Morphological Sciences1,
Pelican County Hospithal of Oradea, Clinical Service of Pathology2
Western University of Vasile Goldis, Arad, Medicine, Dental Medicine and Pharmacy Faculty, Department of General Medicine, Anatomy3
Abstract: The aim of this study was to use a pannel of antibody/ immunohistochimical markers four lung adenocarcinoma such as Ck 7, Ck 20, TTF – 1,and CD – 15, CEA in differentiating primary from metastatic lung adenocarcinoma. The immunohistochemical markers should always be used in conjunction with the clinical presentation, distribution of the lesions, and the morphology. Have been under study 292 patients with lung carcinoma and in 86 ( 29,45 %).cases we foud adenocarcinoma. On these cases we use a pannel of immunohistochimical markers: Ck 7, Ck 20, TTF- 1, and CD – 15, CEA. Of the 86 lung adenocarcinoma specimens there were 40 primary lung adenocarcinomas, 16 metastatic adenocarcinomas from breast and 30 metastatic adenocarcinomas from colon. We have found that 70% of primary lung adenocarcinomas expressed TTF – 1, whereas all nonpulmonary adenocarcinomas lacked TTF – 1 staining. A combination of TTF – 1+/ Ck 7 +/ Ck 20 –/ was highly significantly associated with primary adenocarcinoma of lung. A combination of TTF – 1 –/ Ck 7 –/ Ck 20 +/ was highly significantly associated with adenocarcinoma of gastrointestinal origin. Our study has confirmed that expression of Ck 7 , Ck 20, TTF – 1 and CD – 15, CEA are useful immunohistochemical markers for diagnosis of lung tumors and for differential diagnosis of primary lung adenocarcinomas from metastatic lung adenocarcinomas .Application of this panel of antibodies might be expected to increase the accuracy of diagnosis.
Keywords: lung carcinoma, adenocarcinoma,: Ck 7, Ck 20, TTF – 1, CD – 15, CEA
References: 1. Colby TV, Koss M, Travis WD (1995). Tumors of the Lower Respiratory Tract. 3rd ed. Armed Forces Institute of Pathology: Washington, DC,.
2. Inamura, K. Et al. Pulmonary adenocarcinomas with enteric differentiation (2005). Histologic and immnunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas. American Journal Surgical Pathology; 29: 660 – 665.
3. Khuder SA, (2001). Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer 31: 139-148,.
4. Ordonez N; (2001). Value of thyroid transcription factor -1 immunostaining in distinguishing small cell lung carcinoma from other small carcinomas. American Journal Surgical Pathology 25: 363 – 372.
5. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (2002). Cancer Incidence in Five Continents, Vol. VIII. IARC Scientific Publications No. 155. IARCPress: Lyon.
6. Rekhi, B. et al, (2008). Clinicopathological features and the value of differential Cytokeratin 7 and 20 expression in resolving diagnostic dilemmas of ovarian involvement by colorectal adenocarcinoma and vice – versa. Diagnostic Pathology; 3: 39 – 45.
7. Rossi, G. et al, (2007). Primary lung cancer presenting with gastrointestinal tract involvement: Clinicopathologic and immunohistochemical features in a series of consecutive cases. Journal of Thoracic Oncology ; 2: 115 – 120.
8. Rubin BP, et al, (2001). Use of Citokeratin 7 and Citokeratin 20 in determining the origin of metastatic carcinoma of unknown primary, with special emphasis on lung cancer. European Journal of Cancer Prevention ; 10: 72 – 82.
9. Sack M. J, et al, (1997). Cytokeratins 20 and 7 in the differential diagnosis of metastatic carcinoma in cytologic specimens. Diagnostic Cytopathology ; 16: 132 – 136.
10. Tsao SC, et al, (2007). Use of caveolin – 1, thyroid transcription factor -1, and cytokerantins 7 and 20 in discriminating between primary and secondary pulmonary adenocarcinoma from breast or colonic origin. Kaohsiung Journal of Medical Sciences; 23: 325 – 331.
11. Wang HL. et al, (2001). Immunohistochemical Distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. American Journal Surgical Pathology; 25 (11): 1380 – 1387.
12. Zamecnik J, Kodet R. (2002). Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch 440: 353-361.
Read_full_article: pdf/vol17/iss1/1 JMA 2014 ADENOCARCINOMA PRIMARY IN THE LUNG VERSUS METASTATIC.doc – articol 2014..
Correspondence: Adina Ciursaș* M.D. – univ. assistent on Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University Oradea, street December 1, Oradea, Romania
Adina Ciursas: street Călugăreni nr. 8, bl.C2, ap. 40, Oradea Romania mobile phone: 0728 003 426, e – mail: adina.ciursas@gmail.com,
Pelican County Hospital of Oradea, Clinical Service of Pathology, Corneliu Coposu street nr.2, phone:0259 422078 Oradea, Romania

Read full article
Article Title: ADENOCARCINOMA, PRIMARY IN THE LUNG VERSUS METASTATIC
IMMUNOHISTOCHEMICAL MARKERS
Authors: ADINA CIURSAȘ*1, T.T.MAGHIAR1, M. PUȘCAȘIU1´2, GABRIELA MUȚIU1, P DEME3
Affiliation: University of Oradea, Medicine and Pharmacy Faculty, Department of Morphological Sciences1,
Pelican County Hospithal of Oradea, Clinical Service of Pathology2
Western University of Vasile Goldis, Arad, Medicine, Dental Medicine and Pharmacy Faculty, Department of General Medicine, Anatomy3
Abstract: The aim of this study was to use a pannel of antibody/ immunohistochimical markers four lung adenocarcinoma such as Ck 7, Ck 20, TTF – 1,and CD – 15, CEA in differentiating primary from metastatic lung adenocarcinoma. The immunohistochemical markers should always be used in conjunction with the clinical presentation, distribution of the lesions, and the morphology. Have been under study 292 patients with lung carcinoma and in 86 ( 29,45 %).cases we foud adenocarcinoma. On these cases we use a pannel of immunohistochimical markers: Ck 7, Ck 20, TTF- 1, and CD – 15, CEA. Of the 86 lung adenocarcinoma specimens there were 40 primary lung adenocarcinomas, 16 metastatic adenocarcinomas from breast and 30 metastatic adenocarcinomas from colon. We have found that 70% of primary lung adenocarcinomas expressed TTF – 1, whereas all nonpulmonary adenocarcinomas lacked TTF – 1 staining. A combination of TTF – 1+/ Ck 7 +/ Ck 20 –/ was highly significantly associated with primary adenocarcinoma of lung. A combination of TTF – 1 –/ Ck 7 –/ Ck 20 +/ was highly significantly associated with adenocarcinoma of gastrointestinal origin. Our study has confirmed that expression of Ck 7 , Ck 20, TTF – 1 and CD – 15, CEA are useful immunohistochemical markers for diagnosis of lung tumors and for differential diagnosis of primary lung adenocarcinomas from metastatic lung adenocarcinomas .Application of this panel of antibodies might be expected to increase the accuracy of diagnosis.
Keywords: lung carcinoma, adenocarcinoma,: Ck 7, Ck 20, TTF – 1, CD – 15, CEA
References: 1. Colby TV, Koss M, Travis WD (1995). Tumors of the Lower Respiratory Tract. 3rd ed. Armed Forces Institute of Pathology: Washington, DC,.
2. Inamura, K. Et al. Pulmonary adenocarcinomas with enteric differentiation (2005). Histologic and immnunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas. American Journal Surgical Pathology; 29: 660 – 665.
3. Khuder SA, (2001). Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer 31: 139-148,.
4. Ordonez N; (2001). Value of thyroid transcription factor -1 immunostaining in distinguishing small cell lung carcinoma from other small carcinomas. American Journal Surgical Pathology 25: 363 – 372.
5. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (2002). Cancer Incidence in Five Continents, Vol. VIII. IARC Scientific Publications No. 155. IARCPress: Lyon.
6. Rekhi, B. et al, (2008). Clinicopathological features and the value of differential Cytokeratin 7 and 20 expression in resolving diagnostic dilemmas of ovarian involvement by colorectal adenocarcinoma and vice – versa. Diagnostic Pathology; 3: 39 – 45.
7. Rossi, G. et al, (2007). Primary lung cancer presenting with gastrointestinal tract involvement: Clinicopathologic and immunohistochemical features in a series of consecutive cases. Journal of Thoracic Oncology ; 2: 115 – 120.
8. Rubin BP, et al, (2001). Use of Citokeratin 7 and Citokeratin 20 in determining the origin of metastatic carcinoma of unknown primary, with special emphasis on lung cancer. European Journal of Cancer Prevention ; 10: 72 – 82.
9. Sack M. J, et al, (1997). Cytokeratins 20 and 7 in the differential diagnosis of metastatic carcinoma in cytologic specimens. Diagnostic Cytopathology ; 16: 132 – 136.
10. Tsao SC, et al, (2007). Use of caveolin – 1, thyroid transcription factor -1, and cytokerantins 7 and 20 in discriminating between primary and secondary pulmonary adenocarcinoma from breast or colonic origin. Kaohsiung Journal of Medical Sciences; 23: 325 – 331.
11. Wang HL. et al, (2001). Immunohistochemical Distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. American Journal Surgical Pathology; 25 (11): 1380 – 1387.
12. Zamecnik J, Kodet R. (2002). Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch 440: 353-361.
*Correspondence: Adina Ciursaș* M.D. – univ. assistent on Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University Oradea, street December 1, Oradea, Romania
Adina Ciursas: street Călugăreni nr. 8, bl.C2, ap. 40, Oradea Romania mobile phone: 0728 003 426, e – mail: adina.ciursas@gmail.com,
Pelican County Hospital of Oradea, Clinical Service of Pathology, Corneliu Coposu street nr.2, phone:0259 422078 Oradea, Romania