SYNTHESIS AND CHARACTERIZATION OF GLYCOMONOMER ACRYLOYL 2,3:5,6-DI-O ISOPROPYLIDENE-α-D-MANNOFURANOSIDE

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Article Title:	SYNTHESIS AND CHARACTERIZATION OF GLYCOMONOMER ACRYLOYL 2,3:5,6-DI-O ISOPROPYLIDENE-α-D-MANNOFURANOSIDE
Authors:	Ioana Ramona Ciopănoiu1*, Geza-Nicolae Bandur2, Lucian-Mircea Rusnac2
Affiliation:	1. Faculty of Medicine, Pharmacy and Dental Medicine, “Vasile Goldiș” Western University of Arad, 86 Liviu Rebreanu, 310045, Arad, Romania 2. Faculty of Industrial Chemistry and Environmental Engineering, “Politehnica” University of Timişoara, 6 Carol Telbisz, 300001, Timișoara, Romania
Abstract:	Synthetic carbohydrate polymers are being increasingly investigated as biodegradable, biocompatible and biorenewable materials for use as medical devices, water absorbents or chromatographic supports. The aim of this work was to obtain a monosaccharide ester that possesses a double bond in the molecule and can thus function as a monomer. This was accomplished by reacting 2,3:5,6-diisopropylidene-D-mannofuranose with acryloyl chloride in alkaline medium and with methylene chloride as solvent, using triethylamine as capturing agent for the hydrochloric acid. The structure of the glycomonomer thus obtained was confirmed by nuclear magnetic resonance spectroscopy, Fourier transformed infrared spectroscopy and electrospray ionization mass spectrometry.
Keywords:	glycomonomer, mannose, chemical synthesis, biorenewable, biocompatible
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*Correspondence:	Ioana Ramona Ciopănoiu, “Vasile Goldiş” Western University of Arad, Faculty of Medicine, Pharmacy and Dental Medicine, Department of Pharmaceutical Sciences, 86 Liviu Rebreanu, 310045, Arad, Romania, Tel. +40729806064, email: salageanioana@yahoo.com