The Effect of Eryngium campestre Tincture on Turpentine Oil-Induced Acute Inflammation Model in Rats
April 20, 2011
| Abstract Title: | The Effect of Eryngium campestre Tincture on Turpentine Oil-Induced Acute Inflammation Model in Rats |
| Authors: | Suciu Simona1, Pârvu Alina Elena2 |
| Affiliation: | 1 Vasile Goldis West University, Arad, Department of Clinical Pharmacy, Arad, Romania, suciu_simona@yahoo.com; 2 Iuliu Haţieganu University of Medicine and Pharmacy, Department of Pathophysiology, Faculty of Medicine, Cluj-Napoca, Romania |
| Abstract text: | Aim. Effect of the 20% tincture of the indigenous Eryngium campestre (Apiaceae) was studied by a turpentine-oil induced experimental inflammation in rats. Material and Methods. Experiments were carried out on 4 groups of 8 adult male Wistar rats (150-170g b.w.). Turpentine oil was administrated to all animals (i.m., 6 mL/Kg b.w.) in order to induce the inflammation. After 15 minutes, animals were treated i.p. as follows: group 1 – 20% E. campestre tincture (40 mg plant material/Kg b.w.) diluted in sterile saline, group 2 – 20% E. campestre tincture (200mg/Kg b.w.) diluted in sterile saline, group 3 (control) – sterile saline and group 4 – diclofenac (20 mg/Kg b.w.). Effects were quantified by measuring serum nitrites and nitrates (Griess assay), total oxidative status (TOS), total antioxidant activity/response (TAR) and index of oxidative status (IOS). An in vitro phagocytosis test was also employed in order to determine the phagocytosis index (PI) and phagocytosis activity (PA). Total leukocytes and differential leukocytes were counted. Results and discussions. E. campestre tincture decreased significantly the total leukocytes count compared to control (p |
| Keywords: | Eryngium, leukocytes, NO, oxidative stress, phagocytosis |
| Presentation type: | Oral |
| Correspondence: | Bd. Republicii nr. 17, ap. 10, Baia Mare, Maramures, Romania |
| Email: | suciu_simona@yahoo.com |
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