Prevalence of genetic factors among subjects seeking advice on osteoporosis
April 18, 2010
| Abstract Title: | Prevalence of genetic factors among subjects seeking advice on osteoporosis |
| Authors: | Cevei Mariana*, Stoicanescu Dorina** |
| Affiliation: | *University of Oradea **University of Medicine and Pharmacy “Victor Babes” Timisoara, Romania |
| Abstract text: | Osteoporosis is a multifactorial disease characterized by a decrease in bone mass and deterioration of bone architecture. There is a genetic contribution to the etiology of osteoporosis, genetic factors determining peak bone mass and influencing age-related decreases of bone mass. The magnitude of individual genetic effects differs in different population subsets and in different environments. The heritability of bone density, measured by a several methods in twin studies and family inter-generational studies, has been shown to be very high. This study included a group of 82 patients investigated by DXA for detecting osteoporosis, admitted in the Rehabilitation Clinical Hospital of Baile Felix between July 2008 – May 2009, with a mean age of 61.6 ± 8.8 years, ranging between 44 and 81 years. 48 % of the cases with vertebral osteoporosis had affected parents. From the patients with generalized osteoporosis, 29% had at least one affected parent and when considering the subjects with osteopenia, 22.5% of them had a parent with osteoporosis. Familial predisposition is considered to be an important risk factor, together with early menopause, kyphosis, vitamin D deficiency, no milk uptake, body mass index, etc. Quantification of the risk influences therapeutic decision and informing patients about this risk contributes to the prevention of fragility fractures. |
| Keywords: | osteoporosis, genetic factors, fragility fractures |
| Presentation type: | Poster |
| Correspondence: | University of Oradea |
| Email: | cevei_mariana@yahoo.com |
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