Spleen structural and ultrastructural damages at Wistar rats after Epirubicin administration
April 18, 2010
| Abstract Title: | Spleen structural and ultrastructural damages at Wistar rats after Epirubicin administration |
| Authors: | Popa Laura Cristina, Mariasiu Teodora, Horga Adeline Larisa, Hermenean Anca |
| Affiliation: | Department of Histology, Faculty of Medicine, Pharmacy and Dental Medicine, “Vasile Goldis” Western University, Arad, Romania |
| Abstract text: | The Epirubicin is a frequently used cytostatic drug in the anti-cancer chemotherapy. Unfortunately, the administration of the drug is accompanied by side effects which mainly affect the lymphoid organs. In this experiment, we have analyzed the Wistar rats’ spleen structural and ultrastructural changes for 24 hours after the epirubicin 3 consecutive administration and the ability of its morphological recovering after 10 days of finished treatment. The 24 hours spleen histopathological and electron microscopy examination after epirubicin last dose administration demonstrated the installations of some major structural changes especially at the white pulp level in a necrobiosis and apoptosis different lymphocytes stages, the loss of intercellular contacts. Spleen morphological alterations, although profound, are transitory. Since 10 days from the epirubicin therapy ending, the spleen starts to recover, a fact demonstrated mainly by the compensatory hematopoiesis launching. In conclusion, the immune system normal morpho-functionality resume represents a drug therapy cancer reoccurring. |
| Keywords: | epirubicin, spleen morpho-functional damages, reversible side effects |
| Presentation type: | Oral |
| Correspondence: | no. 1 Feleacului St., Arad, Romania |
| Email: | pcristina2000@yahoo.com |
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