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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
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CORRELATIONS BETWEEN LEFT VENTRICULAR EJECTION FRACTION REDUCTION AND HEART RATE VARIABILITY PDF Print E-mail

CORRELATIONS BETWEEN LEFT VENTRICULAR EJECTION FRACTION REDUCTION AND HEART RATE VARIABILITY

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Title: CORRELATIONS BETWEEN LEFT VENTRICULAR EJECTION FRACTION REDUCTION AND HEART RATE VARIABILITY
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Article_Title: CORRELATIONS BETWEEN LEFT VENTRICULAR EJECTION FRACTION REDUCTION AND HEART RATE VARIABILITY
Authors: Cristiana Buştea1, Delia Mirela Ţiţ2*, Simona Bungău2, Cristian Sava3, Cristian Gheorghe Furău4, Anca Maria Sabău5, Cristian Buştea6
Affiliation: 1Preclinical disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
2Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
3Medical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
4Life Sciences Department, Faculty of Medicine, Western University “Vasile Goldiş” of Arad, Arad
5Department of Physical Education, Sport and Kinetotherapy, Faculty of Geography, Tourism and Sport, University of Oradea, Oradea
6Surgical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
Abstract: The decrease of heart rate variability after acute myocardial infarction has been proved to be a predictor of both sudden death from any cause and sudden cardiac death. Decreased left ventricle ejection fraction is a negative prognostic factor in patients with acute myocardial infarction. Considering this, we intended to prove that there is a correlation between the decrease in the sinus rhythm variability and the degree of reduction of the left ventricle ejection fraction. We measured seven time domain parameters of heart rate variability in patients with acute myocardial infarction (7-10 days after the onset of the infarction; and low ejection fraction of the left ventricle. Parameters of the heart rate variability decreased progressively with the decrease of left ventricle ejection fraction. For patients with LVEF<20%, the decrease of the parameters was statistically significant. The inclusion of patients with severely altered systolic function among acute myocardial infarction surviving patients may alter the prognostic value of heart rate variability indices.
Keywords: heart rate variability, left ventricular ejection fraction, prognostic factor, sinus rhythm variability.
References: Altman DG. Practical statistics for medical research. 1st ed. Chapman & Hall/CR, London, 1999.
Antman E, Bassand JP, Klein W, Ohman M, Sendon JLL, Ryden L et al. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction: The Joint European Society of Cardiology/ American College of Cardiology Committee. J Am Coll Cardiol, 36(3), 959-69, 2000.
Bonaduce D, Petretta M, Marciano F, Vicario M, Apicella C, Rao M, et al. Independent and Incremental Prognostic Value of Heart Rate Variability in Patients with Chronic Heart Failure. Am Heart J, 138 (2), 273-84, 1999.
Bustea C. Changing parameters of sinus rhythm variability in acute myocardial infarction - diagnostic and prognostic significance [PhD Thesis]. University of Oradea, 2009.
Danon A, Schliamser JE, Lavi I, Militianu A. Programmed electrical stimulation for risk stratification of patients with ischemic cardiomyopathy. J Arrhythm, 31, 147-51, 2015.
Hohnloser SH, Verrier RL, Lown B. Effects of adrenergic and muscarinic receptor stimulation on serum potassium concentrations and myocardial electrical stability. Cardiovasc Res, 20, 891-6, 1986.
Huikuri HV, Mäkikallio TH, Peng CK, Goldeberger A, Hintze U, Moller M. Fractal Correlation Properties of R-R Interval Dynamics and Mortality in Patients With Depressed Left Ventricular Function After an Acute Myocardial Infarction. Circulation, 101,47-53, 2000.
Ingale V, Nalbalwar S, Das N. Heart Rate Variability Analysis of Normal Sinus Rhythm, Atrial Fibrillation and Supraventricular Arrhythmia Using ApEn, HRV Index and LFHF Ratio. Internat J Scie Eng Res, 5, 176, 2014.
Kleiger RE, Miller JP, Bigger JTJ, Moss AJ. Multicenter Post-infarction Research Group Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol, 59, 256-62, 1987.
Krstacic A, Krstacic G, Gamberger D, Control of heart rate by the autonomic nervous system in acute spinal cord injury. Acta Clin Croat, 52, 430-5, 2013.
La Gerche A, Burns AT, Mooney DJ, Inder WJ, Taylor AJ, Bogaert J, Mac Isaac AI, Heidbüchel H, Prior DL, Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Euro Heart J, 33(8), 998-1006, 2012.
Makikallio TH, Barthel P, Schneider R, Bauer A, Tapanainen J, Tulppo MP. Prediction of sudden cardiac death after acute myocardial infarction: role of Holter monitoring in the modern treatment era. Eur Heart J, 26(8), 762-9, 2005.
Mansier P, Clairambault J, Charlotte N, Medigue C, Vermeiren C, LePape G, Carré F, Gounaropoulou A, Swynghedauw B. Linear and non-linear analyses of heart rate variability: a minireview. Cardiovasc Res, 31, 371-9, 1996.
Nolan J, Batin PD, Andrews R, Lindsay SJ, Brooksby P, Mullen M, et al. Prospective study of heart rate variability and moratality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation, 98(15), 1510-6, 1998.
Schneider RA, Costiloe P. Relationship of sinus arrhythmia to age and its prognostic significance in ischemic disease. Clin Res, 13, 219, 1965.
Stoicescu M, Csepento C, Muţiu G, Bungau S, The role of increased level of plasma renin in etiopathogenic arterial hypertension in the young. Rom J Morphol Embriol, 52, 419-23, 2011.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability Standards of measurement, physiological interpretation, and clinical use. Eur Heart J, 17, 354-81, 1996.
Wolf MM, Hunt D, Sloman JG. Sinus arrhythmia in acute myocardial infarction. Med J Aust 1978; 2: 52-3.
Yoshikawa T, Baba A, Akaishi M, Mitamura H, Ogawa S, Suzuki M, et al. Neurohumoral Activations in Congestive Heart Failure: Correlations with Cardiac Function, Heart Rate Variability, and Baroreceptor Sensitivity. Am Heart J, 137(4), 666-71, 1999.
Read_full_article: pdf/vol20/iss2/3 JMA 2017 - Bustea et al Arad.pdf
Correspondence: Delia Mirela Tit, University of Oradea Faculty of Medicine and Pharmacy, Department of Pharmacy N. Jiga, 29, 410028, Oradea, Romania, Tel. +4 0742 963 812, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Read full article
Article Title: CORRELATIONS BETWEEN LEFT VENTRICULAR EJECTION FRACTION REDUCTION AND HEART RATE VARIABILITY
Authors: Cristiana Buştea1, Delia Mirela Ţiţ2*, Simona Bungău2, Cristian Sava3, Cristian Gheorghe Furău4, Anca Maria Sabău5, Cristian Buştea6
Affiliation: 1Preclinical disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
2Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
3Medical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
4Life Sciences Department, Faculty of Medicine, Western University “Vasile Goldiş” of Arad, Arad
5Department of Physical Education, Sport and Kinetotherapy, Faculty of Geography, Tourism and Sport, University of Oradea, Oradea
6Surgical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
Abstract: The decrease of heart rate variability after acute myocardial infarction has been proved to be a predictor of both sudden death from any cause and sudden cardiac death. Decreased left ventricle ejection fraction is a negative prognostic factor in patients with acute myocardial infarction. Considering this, we intended to prove that there is a correlation between the decrease in the sinus rhythm variability and the degree of reduction of the left ventricle ejection fraction. We measured seven time domain parameters of heart rate variability in patients with acute myocardial infarction (7-10 days after the onset of the infarction; and low ejection fraction of the left ventricle. Parameters of the heart rate variability decreased progressively with the decrease of left ventricle ejection fraction. For patients with LVEF<20%, the decrease of the parameters was statistically significant. The inclusion of patients with severely altered systolic function among acute myocardial infarction surviving patients may alter the prognostic value of heart rate variability indices.
Keywords: heart rate variability, left ventricular ejection fraction, prognostic factor, sinus rhythm variability.
References: Altman DG. Practical statistics for medical research. 1st ed. Chapman & Hall/CR, London, 1999.
Antman E, Bassand JP, Klein W, Ohman M, Sendon JLL, Ryden L et al. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction: The Joint European Society of Cardiology/ American College of Cardiology Committee. J Am Coll Cardiol, 36(3), 959-69, 2000.
Bonaduce D, Petretta M, Marciano F, Vicario M, Apicella C, Rao M, et al. Independent and Incremental Prognostic Value of Heart Rate Variability in Patients with Chronic Heart Failure. Am Heart J, 138 (2), 273-84, 1999.
Bustea C. Changing parameters of sinus rhythm variability in acute myocardial infarction - diagnostic and prognostic significance [PhD Thesis]. University of Oradea, 2009.
Danon A, Schliamser JE, Lavi I, Militianu A. Programmed electrical stimulation for risk stratification of patients with ischemic cardiomyopathy. J Arrhythm, 31, 147-51, 2015.
Hohnloser SH, Verrier RL, Lown B. Effects of adrenergic and muscarinic receptor stimulation on serum potassium concentrations and myocardial electrical stability. Cardiovasc Res, 20, 891-6, 1986.
Huikuri HV, Mäkikallio TH, Peng CK, Goldeberger A, Hintze U, Moller M. Fractal Correlation Properties of R-R Interval Dynamics and Mortality in Patients With Depressed Left Ventricular Function After an Acute Myocardial Infarction. Circulation, 101,47-53, 2000.
Ingale V, Nalbalwar S, Das N. Heart Rate Variability Analysis of Normal Sinus Rhythm, Atrial Fibrillation and Supraventricular Arrhythmia Using ApEn, HRV Index and LFHF Ratio. Internat J Scie Eng Res, 5, 176, 2014.
Kleiger RE, Miller JP, Bigger JTJ, Moss AJ. Multicenter Post-infarction Research Group Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol, 59, 256-62, 1987.
Krstacic A, Krstacic G, Gamberger D, Control of heart rate by the autonomic nervous system in acute spinal cord injury. Acta Clin Croat, 52, 430-5, 2013.
La Gerche A, Burns AT, Mooney DJ, Inder WJ, Taylor AJ, Bogaert J, Mac Isaac AI, Heidbüchel H, Prior DL, Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Euro Heart J, 33(8), 998-1006, 2012.
Makikallio TH, Barthel P, Schneider R, Bauer A, Tapanainen J, Tulppo MP. Prediction of sudden cardiac death after acute myocardial infarction: role of Holter monitoring in the modern treatment era. Eur Heart J, 26(8), 762-9, 2005.
Mansier P, Clairambault J, Charlotte N, Medigue C, Vermeiren C, LePape G, Carré F, Gounaropoulou A, Swynghedauw B. Linear and non-linear analyses of heart rate variability: a minireview. Cardiovasc Res, 31, 371-9, 1996.
Nolan J, Batin PD, Andrews R, Lindsay SJ, Brooksby P, Mullen M, et al. Prospective study of heart rate variability and moratality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation, 98(15), 1510-6, 1998.
Schneider RA, Costiloe P. Relationship of sinus arrhythmia to age and its prognostic significance in ischemic disease. Clin Res, 13, 219, 1965.
Stoicescu M, Csepento C, Muţiu G, Bungau S, The role of increased level of plasma renin in etiopathogenic arterial hypertension in the young. Rom J Morphol Embriol, 52, 419-23, 2011.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability Standards of measurement, physiological interpretation, and clinical use. Eur Heart J, 17, 354-81, 1996.
Wolf MM, Hunt D, Sloman JG. Sinus arrhythmia in acute myocardial infarction. Med J Aust 1978; 2: 52-3.
Yoshikawa T, Baba A, Akaishi M, Mitamura H, Ogawa S, Suzuki M, et al. Neurohumoral Activations in Congestive Heart Failure: Correlations with Cardiac Function, Heart Rate Variability, and Baroreceptor Sensitivity. Am Heart J, 137(4), 666-71, 1999.
*Correspondence: Delia Mirela Tit, University of Oradea Faculty of Medicine and Pharmacy, Department of Pharmacy N. Jiga, 29, 410028, Oradea, Romania, Tel. +4 0742 963 812, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it