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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
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ASSESSING THE INCIDENCE OF RISK FACTORS AND COMORBIDITIES ASSOCIATED WITH DEMENTIA OF THE ELDERLY PDF Print E-mail

ASSESSING THE INCIDENCE OF RISK FACTORS AND COMORBIDITIES ASSOCIATED WITH DEMENTIA OF THE ELDERLY

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Title: ASSESSING THE INCIDENCE OF RISK FACTORS AND COMORBIDITIES ASSOCIATED WITH DEMENTIA OF THE ELDERLY
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Article_Title: ASSESSING THE INCIDENCE OF RISK FACTORS AND COMORBIDITIES ASSOCIATED WITH DEMENTIA OF THE ELDERLY
Authors: Lavinia Purza1,2, Georgeta Pașca3, Sorin Iova3, Adriana Belba3,
Liviu Lazăr3, Delia Mirela Țiț2*, Diana Uivaroșan4
Affiliation: 1 Doctoral School of Biomedical Sciences, University of Oradea, Oradea
2Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
3 Psycho-Neurosciences and Recovery Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
4Preclinical disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
Abstract: The objective of this study is to assess the prevalence of the risk factors and comorbidities associated with various types of dementia in elderly people. A group of 162 patients with various types of dementia (Alzheimer's, mixed, senile and unspecified) hospitalized at G. Curteanu Clinic Hospital in Oradea during 2012-2016, was studied.
The following parameters in the clinical observation file were followed: sex, background, age, studies, marital status, diagnosis, associated pathologies and MMSE (Mini Mental State Examination) score.
MMSE was used to evaluate cognitive functionality. The patients were aged between 61 and 92 years, 19.75% being male and 80.25% females. The degree of professional training of the patients was low, 50% of them had only primary education. Of the co-morbidities, cardiovascular diseases have the highest prevalence among dementia subjects included in the study.
Keywords: Alzheimer, dementia, risk factors, comorbidities.
References: Grossman HT, Fallon JT, Purohit DP, Perl DP, Siddiqui A, Lesser G, Rosendorff C, Haroutunian V. Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. Neurology , 66(9), 1399-1404, 2006.
FAG de Bruijn R, Ikram MA, Cardiovascular risk factors and future risk of Alzheimer’s disease, BMC Medicine,12:130, 2014.
Cheng G, Huang C, Deng H, Wang H, Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies IMJ, 42(5), 484-491, 2012.
Clague F, Mercer SW, McLean G, Reynish E, and Guthrie B, Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data, Age and Ageing, 46(1), 33-39, 2017.
Deane R, DuYan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, et al., Rage mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med., 9, 907-913, 2003.
Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD, Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease, Lancet, 354, 919-20, 1999.
Gibbs RB, Aggarwal P, Estrogen and basal forebrain cholinergic neurons: implications for brain aging and Alzheimer’s disease-related cognitive decline, Horm Behav, 34(2), 98-111, 1998.
Gibbs RB, Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging, Ann N Y Acad Sci, 743, 165–196, discussion 197-169, 1994.
Goldberg I, Auriel E, Russell D, Korczyn AD: Microembolism, silent brain infarcts and dementia, J Neurol Sci, 322, 250-253, 2012.
Gudala K, Bansal D, Schifano F, Bhansali A, Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies, J Diabetes Invest, 4(6), 640-650, 2013.
Hebert LE, Weuve J, Scherr PA, Evans DA, Alzheimer disease in the United States (2010–2050) estimated using the 2010 census, Neurology, 80(19), 1778-1783, 2013.
Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein, J Biol Chem, 269(18), 13065-13068, 1994.
Karp A, Kåreholt I, Qiu C, Bellander T, Winblad B, Fratiglion IL, Relation of education and occupation-based socioeconomic status to incident Alzheimer’s disease, Am J Epidemiol, 159, 175-183, 2004.
Mielke MM, Vemuri P, Rocca WA, Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences, Clinical Epidemiology, 6, 37-48, 2014.
Ngandu T, von Strauss E, Helkala EL, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M, Education and dementia: what lies behind the association?, Neurology, 69, 1442-1450, 2007.
Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function, BMC Neurosci, 7, 74, 2006.
Newman AB, Fitzpatrick AL, Lopez O, Jackson S, Lyketsos C, Jagust W, Ives D, Dekosky ST, Kuller LH. Dementia and Alzheimer’s disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort, J Am Geriatr Soc, 53, 1101-1107, 2005.
Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study, Neuroepidemiology, 29(12), 125132, 2007.
Plassman BL, Williams JWJr, Burke JR, Holsinger T, and Benjamin S, Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life, Annals of Internal Medicine, 153(3), 182–193, 2010.
Povovaa J, Ambroza P, Barb M, Pavukovaa V, Seryc O, Tomaskovaa H, Janouta V, Epidemiological of and risk factors for Alzheimer‘s disease: A review, Biomed Pap, 156(2), 108-114, 2012.
Qiu C, Bäckman L, Winblad B, Agüero-Torres H, Fratiglioni L, The influence of education on clinically diagnosed dementia: incidence and mortality data from the Kungsholmen Project, Arch Neurol, 58,2034-2039, 2001.
Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease, Nat Rev Neurol, 7(3), 137-152, 2011.
Ransohoff RM, How neuroinflammation contributes to neurodegeneration, Science, 353(6301), 777-783, 2016.
Seshadri S, Wolf PA, Beiser A, et al., Lifetime risk of dementia and Alzheimer’s disease. The impact of mortality on risk estimates in the Framingham Study, Neurology, 49(6), 1498-1504, 1997.
Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR, Brain infarction and the clinical expression of Alzheimer disease: the Nun Study, JAMA, 277, 813-7, 1997.
Thies W, Bleiler L, 2013 Alzheimer’s disease facts and figures, Alzheimer’s Demen, 9(2), 208-245, 2013.
de la Torre JC: Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia, Cardiovasc Psychiatry Neurol, 2012, 367516, 2012.
Wang Q, Santizo R, Baughman VL, Pelligrino DA, Iadecola C, Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats, Stroke, 30(3), 630-637, 1999.
Read_full_article: pdf/vol20/iss1/3 JMA  -  Purza L - ASSESSING THE INCIDENCE.pdf
Correspondence: *Correspondence: Delia Mirela Tit, University of Oradea Faculty of Medicine and Pharmacy, Department of Pharmacy N. Jiga, 29, 410028, Oradea, Romania, Tel. +4 0742 963 812, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Read full article
Article Title: ASSESSING THE INCIDENCE OF RISK FACTORS AND COMORBIDITIES ASSOCIATED WITH DEMENTIA OF THE ELDERLY
Authors: Lavinia Purza1,2, Georgeta Pașca3, Sorin Iova3, Adriana Belba3,
Liviu Lazăr3, Delia Mirela Țiț2*, Diana Uivaroșan4
Affiliation: 1 Doctoral School of Biomedical Sciences, University of Oradea, Oradea
2Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
3 Psycho-Neurosciences and Recovery Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
4Preclinical disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea
Abstract: The objective of this study is to assess the prevalence of the risk factors and comorbidities associated with various types of dementia in elderly people. A group of 162 patients with various types of dementia (Alzheimer's, mixed, senile and unspecified) hospitalized at G. Curteanu Clinic Hospital in Oradea during 2012-2016, was studied.
The following parameters in the clinical observation file were followed: sex, background, age, studies, marital status, diagnosis, associated pathologies and MMSE (Mini Mental State Examination) score.
MMSE was used to evaluate cognitive functionality. The patients were aged between 61 and 92 years, 19.75% being male and 80.25% females. The degree of professional training of the patients was low, 50% of them had only primary education. Of the co-morbidities, cardiovascular diseases have the highest prevalence among dementia subjects included in the study.
Keywords: Alzheimer, dementia, risk factors, comorbidities.
References: Grossman HT, Fallon JT, Purohit DP, Perl DP, Siddiqui A, Lesser G, Rosendorff C, Haroutunian V. Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. Neurology , 66(9), 1399-1404, 2006.
FAG de Bruijn R, Ikram MA, Cardiovascular risk factors and future risk of Alzheimer’s disease, BMC Medicine,12:130, 2014.
Cheng G, Huang C, Deng H, Wang H, Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies IMJ, 42(5), 484-491, 2012.
Clague F, Mercer SW, McLean G, Reynish E, and Guthrie B, Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data, Age and Ageing, 46(1), 33-39, 2017.
Deane R, DuYan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, et al., Rage mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med., 9, 907-913, 2003.
Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD, Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease, Lancet, 354, 919-20, 1999.
Gibbs RB, Aggarwal P, Estrogen and basal forebrain cholinergic neurons: implications for brain aging and Alzheimer’s disease-related cognitive decline, Horm Behav, 34(2), 98-111, 1998.
Gibbs RB, Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging, Ann N Y Acad Sci, 743, 165–196, discussion 197-169, 1994.
Goldberg I, Auriel E, Russell D, Korczyn AD: Microembolism, silent brain infarcts and dementia, J Neurol Sci, 322, 250-253, 2012.
Gudala K, Bansal D, Schifano F, Bhansali A, Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies, J Diabetes Invest, 4(6), 640-650, 2013.
Hebert LE, Weuve J, Scherr PA, Evans DA, Alzheimer disease in the United States (2010–2050) estimated using the 2010 census, Neurology, 80(19), 1778-1783, 2013.
Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein, J Biol Chem, 269(18), 13065-13068, 1994.
Karp A, Kåreholt I, Qiu C, Bellander T, Winblad B, Fratiglion IL, Relation of education and occupation-based socioeconomic status to incident Alzheimer’s disease, Am J Epidemiol, 159, 175-183, 2004.
Mielke MM, Vemuri P, Rocca WA, Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences, Clinical Epidemiology, 6, 37-48, 2014.
Ngandu T, von Strauss E, Helkala EL, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M, Education and dementia: what lies behind the association?, Neurology, 69, 1442-1450, 2007.
Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function, BMC Neurosci, 7, 74, 2006.
Newman AB, Fitzpatrick AL, Lopez O, Jackson S, Lyketsos C, Jagust W, Ives D, Dekosky ST, Kuller LH. Dementia and Alzheimer’s disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort, J Am Geriatr Soc, 53, 1101-1107, 2005.
Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study, Neuroepidemiology, 29(12), 125132, 2007.
Plassman BL, Williams JWJr, Burke JR, Holsinger T, and Benjamin S, Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life, Annals of Internal Medicine, 153(3), 182–193, 2010.
Povovaa J, Ambroza P, Barb M, Pavukovaa V, Seryc O, Tomaskovaa H, Janouta V, Epidemiological of and risk factors for Alzheimer‘s disease: A review, Biomed Pap, 156(2), 108-114, 2012.
Qiu C, Bäckman L, Winblad B, Agüero-Torres H, Fratiglioni L, The influence of education on clinically diagnosed dementia: incidence and mortality data from the Kungsholmen Project, Arch Neurol, 58,2034-2039, 2001.
Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease, Nat Rev Neurol, 7(3), 137-152, 2011.
Ransohoff RM, How neuroinflammation contributes to neurodegeneration, Science, 353(6301), 777-783, 2016.
Seshadri S, Wolf PA, Beiser A, et al., Lifetime risk of dementia and Alzheimer’s disease. The impact of mortality on risk estimates in the Framingham Study, Neurology, 49(6), 1498-1504, 1997.
Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR, Brain infarction and the clinical expression of Alzheimer disease: the Nun Study, JAMA, 277, 813-7, 1997.
Thies W, Bleiler L, 2013 Alzheimer’s disease facts and figures, Alzheimer’s Demen, 9(2), 208-245, 2013.
de la Torre JC: Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia, Cardiovasc Psychiatry Neurol, 2012, 367516, 2012.
Wang Q, Santizo R, Baughman VL, Pelligrino DA, Iadecola C, Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats, Stroke, 30(3), 630-637, 1999.
*Correspondence: *Correspondence: Delia Mirela Tit, University of Oradea Faculty of Medicine and Pharmacy, Department of Pharmacy N. Jiga, 29, 410028, Oradea, Romania, Tel. +4 0742 963 812, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it