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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Rank: CNCSIS C (code 292) since 2010

International Database: Index Copernicus Journal Master List Value (2010): 4.66

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THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS PDF Print E-mail

THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS

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Title:THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS
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Article_Title:THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS
Authors:AMALIA NICOLESCU 1, TEODORA OLARIU2
Affiliation:1 Department of Intensive Care, „Vasile Goldis” Western University of Arad, Romania,
2 Department of Intensive Care, „Vasile Goldis” Western University of Arad, Romania
Abstract:Lung cancer (PBC) frequency increased alarmingly in the last decades, especially in economically developed countries. The lymphatic microvascular density can be one of the important factors for prognosis in patients with lung carcinomas. The aim of this study was to analysed the D2-40 and VEGF-C expression in tumor cells and lymphatic vessels in the lung squamous cell carcinoma. Our study included a total of 27 cases. The immunoexpression of VEGF-C and D2-40 was evaluated according to the following score: 0 (0% positive cells), 1 (<10% positive cells), 2 (10-30% positive cells) and 3 (> 30% positive cells). VEGF-C score ranged from 0 to 3. The score 0 was found in 7.40% of cases, score 1 in 14.81%, score 2 in 25.92% and score 3 in 51.85% of cases. The lung squamous cell lung carcinomas showed a positive D2-40 lymphatic vessel density higher in the peritumoral comparatively with the intratumoral area. They may contribute to a better understanding of lung cancer biology and individualised therapies.
Keywords:lung squamous cell carcinoma, D2-40, VEGF-C
References:[1] Schwarz MI, Epstein PE (1999) Pulmonary medicine and critical care. Knowlegde self – assessment Programe. Atlanta.
[2] Alberg A, Samet J (2003) Epidemiology of Lung Cancer. Chest, 123, pp. 21-49.
[3] Al-Rawi MA, Mansel RE, Jiang WG (2005) Lymphangiogenesis and its role in cancer. Histol Histopathol., 20, pp. 283–298.
[4] Inoue A, Moriya H, Katada N, Tanabe S, Kobayashi N, Watanabe M, Okayasu I (2008) Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis. Pathol Int., 58, pp. 611–619.
[5] Jackson DG, Prevo R, Clasper S, Banerji S (2001) LYVE-1, the lymphatic system and tumor lymphangiogenesis. Trends Immunol., 22, pp. 317–321.
[6] Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med, 7, pp. 192–198.
[7] Mattila MM, Ruohola JK, Karpanen T, Jackson DG, Alitalo K, Harkonen P, (2002) VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer., 98, pp. 946–951.
[8] Hu Z, Wang W, Zhang J, Mao F, Shen-Tu Y (2012) Prognostic value of lymphangiogenesis and lymphatic vessel invasion in non-small cell lung cancer. Zhongguo Fei Ai Za Zhi, 15(11), pp. 656-662.
[9] Guo J1, Higashi K, Ueda Y, Oguchi M, Takegami T, Toga H, Sakuma T, Yokota H, Katsuda S, Tonami H, Yamamoto I (2006) Micro vessel density: correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas. J Med., 47(3), pp. 419-425.
[10] Dai X, Wang W, Shen-Tu Y, Zhang J (2011) Expression and prognostic value of VEGF-C and lymphangeogenesis in lung adenocarcinoma and squamous cell carcinoma. Zhongguo Fei Ai Za Zhi, 14(10), pp. 774-779.
[11] Iwakiri S, Nagai S, Katakura H, Takenaka K, Date H, Wada H, Tanaka F (2009) D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung. Ann Surg Oncol., 16(6), pp. 1678-1685.
[12] Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK (2000) Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Res, 60, pp. 4324-4327.
[13] Dadras SS, Bertoncini PT, Brown LF, Muzikansky A, Jackson DG, Ellwanger U, Garbe C, Mihm MC, Detmar M (2004) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am. J. Pathol., 162, pp. 1951-1960.
[14] Valencak J, Heere-Ress E, Kopp T, Schoppmann SF, Kittler H, Pehamberger H (2004) Selective immunohistochemical staining shows significant prognostic influence of lymphatic and blood vessels in patients with malignant melanoma. Eur. J. Cancer, 40, pp. 358-364.
[15] Kyzas P.A., Geleff S., Batistatou A., Agnantis N.J., Stefanou D. (2005) Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J. Pathol., 206, pp. 170-177.
Read_full_article:pdf/vol19/iss3/6 JMA 2016 - Birauz.pdf
Correspondence:Amalia Nicolescu, Western University of Arad, Romania, Department of Intensive Care, Piata Mihai Viteazu, nr. 7-8, tel: (004)0257/257080’, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Read full article
Article Title:THE IMPLICATIONS OF LYMPHANGIOGENESIS IN LUNG SQUAMOUS CELL CARCINOMAS
Authors:AMALIA NICOLESCU 1, TEODORA OLARIU2
Affiliation:1 Department of Intensive Care, „Vasile Goldis” Western University of Arad, Romania,
2 Department of Intensive Care, „Vasile Goldis” Western University of Arad, Romania
Abstract:Lung cancer (PBC) frequency increased alarmingly in the last decades, especially in economically developed countries. The lymphatic microvascular density can be one of the important factors for prognosis in patients with lung carcinomas. The aim of this study was to analysed the D2-40 and VEGF-C expression in tumor cells and lymphatic vessels in the lung squamous cell carcinoma. Our study included a total of 27 cases. The immunoexpression of VEGF-C and D2-40 was evaluated according to the following score: 0 (0% positive cells), 1 (<10% positive cells), 2 (10-30% positive cells) and 3 (> 30% positive cells). VEGF-C score ranged from 0 to 3. The score 0 was found in 7.40% of cases, score 1 in 14.81%, score 2 in 25.92% and score 3 in 51.85% of cases. The lung squamous cell lung carcinomas showed a positive D2-40 lymphatic vessel density higher in the peritumoral comparatively with the intratumoral area. They may contribute to a better understanding of lung cancer biology and individualised therapies.
Keywords:lung squamous cell carcinoma, D2-40, VEGF-C
References:[1] Schwarz MI, Epstein PE (1999) Pulmonary medicine and critical care. Knowlegde self – assessment Programe. Atlanta.
[2] Alberg A, Samet J (2003) Epidemiology of Lung Cancer. Chest, 123, pp. 21-49.
[3] Al-Rawi MA, Mansel RE, Jiang WG (2005) Lymphangiogenesis and its role in cancer. Histol Histopathol., 20, pp. 283–298.
[4] Inoue A, Moriya H, Katada N, Tanabe S, Kobayashi N, Watanabe M, Okayasu I (2008) Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis. Pathol Int., 58, pp. 611–619.
[5] Jackson DG, Prevo R, Clasper S, Banerji S (2001) LYVE-1, the lymphatic system and tumor lymphangiogenesis. Trends Immunol., 22, pp. 317–321.
[6] Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M (2001) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med, 7, pp. 192–198.
[7] Mattila MM, Ruohola JK, Karpanen T, Jackson DG, Alitalo K, Harkonen P, (2002) VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer., 98, pp. 946–951.
[8] Hu Z, Wang W, Zhang J, Mao F, Shen-Tu Y (2012) Prognostic value of lymphangiogenesis and lymphatic vessel invasion in non-small cell lung cancer. Zhongguo Fei Ai Za Zhi, 15(11), pp. 656-662.
[9] Guo J1, Higashi K, Ueda Y, Oguchi M, Takegami T, Toga H, Sakuma T, Yokota H, Katsuda S, Tonami H, Yamamoto I (2006) Micro vessel density: correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas. J Med., 47(3), pp. 419-425.
[10] Dai X, Wang W, Shen-Tu Y, Zhang J (2011) Expression and prognostic value of VEGF-C and lymphangeogenesis in lung adenocarcinoma and squamous cell carcinoma. Zhongguo Fei Ai Za Zhi, 14(10), pp. 774-779.
[11] Iwakiri S, Nagai S, Katakura H, Takenaka K, Date H, Wada H, Tanaka F (2009) D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung. Ann Surg Oncol., 16(6), pp. 1678-1685.
[12] Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK (2000) Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Res, 60, pp. 4324-4327.
[13] Dadras SS, Bertoncini PT, Brown LF, Muzikansky A, Jackson DG, Ellwanger U, Garbe C, Mihm MC, Detmar M (2004) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am. J. Pathol., 162, pp. 1951-1960.
[14] Valencak J, Heere-Ress E, Kopp T, Schoppmann SF, Kittler H, Pehamberger H (2004) Selective immunohistochemical staining shows significant prognostic influence of lymphatic and blood vessels in patients with malignant melanoma. Eur. J. Cancer, 40, pp. 358-364.
[15] Kyzas P.A., Geleff S., Batistatou A., Agnantis N.J., Stefanou D. (2005) Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J. Pathol., 206, pp. 170-177.
*Correspondence:Amalia Nicolescu, Western University of Arad, Romania, Department of Intensive Care, Piata Mihai Viteazu, nr. 7-8, tel: (004)0257/257080’, e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it