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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Rank: CNCSIS C (code 292) since 2010

International Database: Index Copernicus Journal Master List Value (2010): 4.66

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The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction PDF Print E-mail

The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction

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Title: The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction
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Article_Title: The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction
Authors: Corina Zorila1,Liana Mos1, Elena Magopat2, Eva Mera3
Affiliation: 1.Western University “V. Goldis” Arad, 2.Clinical County Emergency Hospital Arad,2d Internal Medicine Clinic, 3.S.C.Clinical Laboratory SRL. Arad, Romania
Abstract: The theory of aging by free radicals agree that age is the the consequence of accumulation of lesions induced by free radicals. We use indirect measurement of lipidperoxidation, which is a measure of the reaction products of free radical damage to the lipid substrate, mainly consisting of membrane polyunsaturated fatty acids. Low plasma levels of Vitamin E has been associated with a risk factor of 2.6 times higher early coronary heart disease. Material and methods. We studied a group of 33 patients with cardiovascular disease and/or hypertension (Group I) of atherosclerotic etiology. We administered 2 x 600 alpha-tocopherol mg /day (Vitamin E) for 7 days in capsules. In order to determine the extension of lipoperoxidation we have determined ATB-reactive substances by the method of Satoh in peripheral venous blood, prior to administration of vitamin E and 7 days after treatment. We compared this group (Group I), with another group of patients with symptomatic ischemic heart disease (Group II) without nutritional supplementation. Results.Baseline there is a average level of substance ATB - reactive similar in the two groups, but significantly lower in Group I after nutritional supplementation with alpha-tocopherol. Conclusions. Alpha-tocopherol supplementation in patients with cardiovascular disease, over 60 years, revealed a significant decrease in lipid peroxidation, with protective effect on endothelial dysfunction
Keywords: aging, lipidperoxidation, vitamin E
References: 1. Burris CA, Ashwood ER, Burns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. St. Louis: Elsevier Saunders; 2006.
2. McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia: Elsevier Saunders; 2011.
3. Wallach J. Interpretation of Diagnostic Tests. 6th ed. New York: Little, Brown; 1996.
4. Bast A, Haenen G, Doelmann C Oxidants et antioxidants la situation actuellle inGSH System, la glutation dans les mechanisms de defense antioxidants Excerpta Amsterdam 1992
5. Chen Mf ,Hsu H, Chen Wi. ,Lee Cm ,Wu C, Liau C :Fish oil supplementation attenuates free radical generation in short term coronary occlusion reperfusion in cholesterol fed rabbits Prostaglandines, Apr. 1997
6. Stefan A.Hulea: An introduction to vitamins, minerals and oxidative stress-the role of micronutrients and reactive oxygen species in normal and pathological processes Universal publishers boca Raton USA 2008.
7. Corina Zorilă -Stresul oxidativ şi afecţiunile vasculare - Ed.”Vasile Goldiş” University Press 2001, ISBN: 973-8161-13-4
Read_full_article: pdf/vol17/iss3-4/18 JMA 2014 - vit E DKMT englezacorectat.pdf
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Read full article
Article Title: The Effect of Vitamin E Supplementation on Lipid Peroxidation in Patients with Endothelial Dysfunction
Authors: Corina Zorila1,Liana Mos1, Elena Magopat2, Eva Mera3
Affiliation: 1.Western University “V. Goldis” Arad, 2.Clinical County Emergency Hospital Arad,2d Internal Medicine Clinic, 3.S.C.Clinical Laboratory SRL. Arad, Romania
Abstract: The theory of aging by free radicals agree that age is the the consequence of accumulation of lesions induced by free radicals. We use indirect measurement of lipidperoxidation, which is a measure of the reaction products of free radical damage to the lipid substrate, mainly consisting of membrane polyunsaturated fatty acids. Low plasma levels of Vitamin E has been associated with a risk factor of 2.6 times higher early coronary heart disease. Material and methods. We studied a group of 33 patients with cardiovascular disease and/or hypertension (Group I) of atherosclerotic etiology. We administered 2 x 600 alpha-tocopherol mg /day (Vitamin E) for 7 days in capsules. In order to determine the extension of lipoperoxidation we have determined ATB-reactive substances by the method of Satoh in peripheral venous blood, prior to administration of vitamin E and 7 days after treatment. We compared this group (Group I), with another group of patients with symptomatic ischemic heart disease (Group II) without nutritional supplementation. Results.Baseline there is a average level of substance ATB - reactive similar in the two groups, but significantly lower in Group I after nutritional supplementation with alpha-tocopherol. Conclusions. Alpha-tocopherol supplementation in patients with cardiovascular disease, over 60 years, revealed a significant decrease in lipid peroxidation, with protective effect on endothelial dysfunction
Keywords: aging, lipidperoxidation, vitamin E
References: 1. Burris CA, Ashwood ER, Burns DE. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. St. Louis: Elsevier Saunders; 2006.
2. McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia: Elsevier Saunders; 2011.
3. Wallach J. Interpretation of Diagnostic Tests. 6th ed. New York: Little, Brown; 1996.
4. Bast A, Haenen G, Doelmann C Oxidants et antioxidants la situation actuellle inGSH System, la glutation dans les mechanisms de defense antioxidants Excerpta Amsterdam 1992
5. Chen Mf ,Hsu H, Chen Wi. ,Lee Cm ,Wu C, Liau C :Fish oil supplementation attenuates free radical generation in short term coronary occlusion reperfusion in cholesterol fed rabbits Prostaglandines, Apr. 1997
6. Stefan A.Hulea: An introduction to vitamins, minerals and oxidative stress-the role of micronutrients and reactive oxygen species in normal and pathological processes Universal publishers boca Raton USA 2008.
7. Corina Zorilă -Stresul oxidativ şi afecţiunile vasculare - Ed.”Vasile Goldiş” University Press 2001, ISBN: 973-8161-13-4
*Correspondence: