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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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THE ROLE OF IODINE IN NORMAL BREAST DEVELOPMENT IN YOUNG MAMMALS PDF Print E-mail

THE ROLE OF IODINE IN NORMAL BREAST DEVELOPMENT IN YOUNG MAMMALS

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Title: THE ROLE OF IODINE IN NORMAL BREAST DEVELOPMENT IN YOUNG MAMMALS
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Article_Title: THE ROLE OF IODINE IN NORMAL BREAST DEVELOPMENT IN YOUNG MAMMALS
Authors: Mihaela Avram1*, Dimitrios Koukoulas2, Iulian Avram1, Bogdan Totolici 3, Sorin Olariu 1
Affiliation: 1 University of Medicine and Pharmacy Timişoara, Faculty of Medicine,1st Surgical Clinic,
2 City Hospital Lugoj, Romania
3“Vasile Goldiş” Western University of Arad – Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
Abstract: Iodine deficiency is an important health problem. Its role in breast pathology and treatment of breast disease has been well studied, but little is known about its role in the development of the breast in young mammals. We conducted a study on 3 weeks old female mice, having an iodine intake of 25% of the necessary, this privation of iodine was created using a special feeding formula and adding sodium perchlorate to the drinking water. After 4 weeks the breast tissues of this group was compared to the control group. The iodine privation prevented normal maturation of breast tissue in the studied lot. Iodine seems to play an important role in breast development in young female mammals.
Keywords: iodine deficiency, breast development, perchlorate
References: O. Soriano, G. Delgado,B. Anguiano, et al.:Antineoplastic effect of iodine and iodide in dimethylbenz[a]anthracene-induced mammary tumors: association between lactoperoxidase and estrogen-adduct production Endocr Relat Cancer 18 (4) 529-539, June 2011
Delange F. 2000 Endemic cretinism. In: Braverman LE, Utiger RD, eds. The thyroid. A fundamental and clinical text. Philadelphia: Lippincott; 743–754.
Hynes K.L.,Otahal P., Hay I., Burgess J.R.: Mild Iodine Deficiency During Pregnancy Is Associated With Reduced Educational Outcomes in the Offspring: 9-Year Follow-up of the Gestational Iodine Cohort JCEM 2013 98: 1954-1962
DeLong GR, Leslie PW, Wang S-H, et al. 1997 Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet. 350:771–773.
Venturi S: Is there a role for iodine in breast diseases? Breast 10:379–382(2001)
Strum J M. Effect of iodide-deficiency on rat mammary gland.Virchows Arch B Cell Pathol Incl Mol Pathol 1979; 30(2):209-220
Aceves C, Anguiano B & Delgado G : Is iodine a gatekeeper of the integrity of the mammary gland? Journal of Mammary Gland Biology and Neoplasia 10189–196, 2005
Cann SA, van Netten JP, van Netten C. Hypothesis: Iodine, selenium and the development of breast cancer. Cancer Causes Control;11:121–127. 2000
Smyth PP. Role of iodine in antioxidant defence in thyroid and breast disease. Biofactors;19:121–130. 2003
Cocchi M, Venturi S. Iodide, antioxidant function and omega-6 and omega-3 fatty acids: A new hypothesis of biochemical cooperation? Prog Nutr 2000;2:15–9.
Avram M, Avram J, Cadariu F, Pasztori M, Avram I, Birsasteanu F.: Epidemiological study of fibrocystic breast changes in Timisoara. Journal of Experimental Medical & Surgical Research 3 • 213 – 218. 2009
Wolff J. Perchlorate and the thyroid gland. Pharmacol Rev 50:89 105,1998.
Greer MA, Goodman G, Pleus RC, Greer SE. Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans. Environ Health Perspect 2002;110:927-937.
Baier-Anderson C, Blount BC, Lakind JS, et al. Estimates of exposures to perchlorate from consumption of human milk, dairy milk and water, and comparison to current reference dose. J Toxicol Environ Health A 2006; 69:319-330.
Read_full_article: pdf/vol17/iss3-4/14 JMA 2014 - Avram - THE ROLE OF IODINE.pdf
Correspondence: Mihaela Avram
Bd. I. Bulbuca 10, 300736 Timişoara, Romania
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Read full article
Article Title: THE ROLE OF IODINE IN NORMAL BREAST DEVELOPMENT IN YOUNG MAMMALS
Authors: Mihaela Avram1*, Dimitrios Koukoulas2, Iulian Avram1, Bogdan Totolici 3, Sorin Olariu 1
Affiliation: 1 University of Medicine and Pharmacy Timişoara, Faculty of Medicine,1st Surgical Clinic,
2 City Hospital Lugoj, Romania
3“Vasile Goldiş” Western University of Arad – Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
Abstract: Iodine deficiency is an important health problem. Its role in breast pathology and treatment of breast disease has been well studied, but little is known about its role in the development of the breast in young mammals. We conducted a study on 3 weeks old female mice, having an iodine intake of 25% of the necessary, this privation of iodine was created using a special feeding formula and adding sodium perchlorate to the drinking water. After 4 weeks the breast tissues of this group was compared to the control group. The iodine privation prevented normal maturation of breast tissue in the studied lot. Iodine seems to play an important role in breast development in young female mammals.
Keywords: iodine deficiency, breast development, perchlorate
References: O. Soriano, G. Delgado,B. Anguiano, et al.:Antineoplastic effect of iodine and iodide in dimethylbenz[a]anthracene-induced mammary tumors: association between lactoperoxidase and estrogen-adduct production Endocr Relat Cancer 18 (4) 529-539, June 2011
Delange F. 2000 Endemic cretinism. In: Braverman LE, Utiger RD, eds. The thyroid. A fundamental and clinical text. Philadelphia: Lippincott; 743–754.
Hynes K.L.,Otahal P., Hay I., Burgess J.R.: Mild Iodine Deficiency During Pregnancy Is Associated With Reduced Educational Outcomes in the Offspring: 9-Year Follow-up of the Gestational Iodine Cohort JCEM 2013 98: 1954-1962
DeLong GR, Leslie PW, Wang S-H, et al. 1997 Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China. Lancet. 350:771–773.
Venturi S: Is there a role for iodine in breast diseases? Breast 10:379–382(2001)
Strum J M. Effect of iodide-deficiency on rat mammary gland.Virchows Arch B Cell Pathol Incl Mol Pathol 1979; 30(2):209-220
Aceves C, Anguiano B & Delgado G : Is iodine a gatekeeper of the integrity of the mammary gland? Journal of Mammary Gland Biology and Neoplasia 10189–196, 2005
Cann SA, van Netten JP, van Netten C. Hypothesis: Iodine, selenium and the development of breast cancer. Cancer Causes Control;11:121–127. 2000
Smyth PP. Role of iodine in antioxidant defence in thyroid and breast disease. Biofactors;19:121–130. 2003
Cocchi M, Venturi S. Iodide, antioxidant function and omega-6 and omega-3 fatty acids: A new hypothesis of biochemical cooperation? Prog Nutr 2000;2:15–9.
Avram M, Avram J, Cadariu F, Pasztori M, Avram I, Birsasteanu F.: Epidemiological study of fibrocystic breast changes in Timisoara. Journal of Experimental Medical & Surgical Research 3 • 213 – 218. 2009
Wolff J. Perchlorate and the thyroid gland. Pharmacol Rev 50:89 105,1998.
Greer MA, Goodman G, Pleus RC, Greer SE. Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans. Environ Health Perspect 2002;110:927-937.
Baier-Anderson C, Blount BC, Lakind JS, et al. Estimates of exposures to perchlorate from consumption of human milk, dairy milk and water, and comparison to current reference dose. J Toxicol Environ Health A 2006; 69:319-330.
*Correspondence: Mihaela Avram
Bd. I. Bulbuca 10, 300736 Timişoara, Romania
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it