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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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PERINATAL AUTOPSY EVALUATION OF 452 AUTOPSIES IN ARAD, ROMANIA PDF Print E-mail

PERINATAL AUTOPSY EVALUATION OF 452 AUTOPSIES IN ARAD, ROMANIA

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Title: PERINATAL AUTOPSY EVALUATION OF 452 AUTOPSIES IN ARAD, ROMANIA
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Article_Title: PERINATAL AUTOPSY EVALUATION OF 452 AUTOPSIES
IN ARAD, ROMANIA
Authors: Dr. Ülgüt Corina¹, Conf.Dr. Paiusan Lucian²
Affiliation: ¹Resident doctor, Morphopathology Departament, “Salvator Vuia” Obstetric and Gynecology Hospital Arad, Romania
²Head of Morphopathology Departament, “Salvator Vuia” Obstetric and Gynecology Hospital Arad, Romania
Abstract: Congenital anomalies have become an important cause of perinatal mortality and morbidity in both developing and developed countries. It has been shown through some studies that these can be reduced substantially by means of improved prenatal, obstetric and postnatal care (1, 2, 5). The aim of this study was to present the incidence of fetal anomalies in our city of Arad, Romania, in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies. The study included 452 autopsies performed between January 2004 and December 2013 at our Hospital of Obstetric and Gynecology “Salvator Vuia” Arad, Romania. Diagnoses were categorized according to the detected pathologies; congenital malformations were detailed based on systems. Congenital malformation were detected in 51,53% of cases, of which 51,50% cardiac malformation, 21,03% neural tube defects and central nervous system malformations, 10,30% pulmonary malformation, 7,30% malformations of the urogenital system, 3,43% malformations of the musculoskeletal system and 1,72% malformations of the face. Cerebral hemorrhage was finding in 93,81% of cases, of which 6,60% with the dilatation of the ventricular system. The role of fetal autopsy remains very important in order to clearly identify some other defects in terminated fetuses. Parents can also be better informed about the possible risks in future pregnancies with the help of the findings received through fetal autopsy so that they can take necessary precautions. A larger number of cases is required for a more accurate evaluation.
Keywords: Autopsy, Fetal diseases, Congenital malformation, Prenatal diagnosis
References: 1. Sloan EP, Kirsh S, Mowbray M: Viewing the fetus following termination of pregnancy for fetal anomaly. JOGNN 2008, 37: 395-404
2. Dickinson JE, Prime DK, Charles AK: The role of autopsy following pregnancy termination for fetal abnormality. ANZJOG 2007, 47: 445-449
3. Nielsen LA, Maroun LL, Broholm H, Laursen H, Graem N: Neural tube defect and associated anomalies in a fetal perinatal autopsy series. APMIS 2006, 114:239-46
4. Bourke J, Bower C, Blair E, Charles A, Knuiman M: Thre effect of termination of pregnancy for fetal abnormalites on trends in mortality to one year of age in Western Australia. Paediatr Perinat Epidemiol 2005, 19:284-293
5. Ceylaner S, Ceylaner G, Gunyeli I, Ekici E, Tug M, Taner D, Ekerbicer H, Mollamahmutoğlu L, Danişman N: Postmortem evaluation of 220 prenataly diagnoses fetuses with neural tube defect detection of associated anomalies in a Turkish population. Prenat Diagn 2006, 26: 147–153
6. Corabian P. Guidelines for investigation stillbirths: an update of a systematic review. J Obstet Gynaecol Can 2007;29:560–7.
7. Gordijn SJ, Erwich JJ, Khong TY. (2002). Value of perinatal autopsy: critique. Pediatr Dev Pathol 2002;5:480–8.
8. Grover N. Congenital malformations in Shimla. Indian J Pediatr. 2000;67:249-51.
Read_full_article: pdf/vol17/iss3-4/13 JMA 2014 - Ulgut - PERINATAL AUTOPSY.pdf
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Article Title: PERINATAL AUTOPSY EVALUATION OF 452 AUTOPSIES
IN ARAD, ROMANIA
Authors: Dr. Ülgüt Corina¹, Conf.Dr. Paiusan Lucian²
Affiliation: ¹Resident doctor, Morphopathology Departament, “Salvator Vuia” Obstetric and Gynecology Hospital Arad, Romania
²Head of Morphopathology Departament, “Salvator Vuia” Obstetric and Gynecology Hospital Arad, Romania
Abstract: Congenital anomalies have become an important cause of perinatal mortality and morbidity in both developing and developed countries. It has been shown through some studies that these can be reduced substantially by means of improved prenatal, obstetric and postnatal care (1, 2, 5). The aim of this study was to present the incidence of fetal anomalies in our city of Arad, Romania, in order to determine the efficiency of prenatal diagnosis through fetal autopsy, and to compare our statistical data with other national and international studies. The study included 452 autopsies performed between January 2004 and December 2013 at our Hospital of Obstetric and Gynecology “Salvator Vuia” Arad, Romania. Diagnoses were categorized according to the detected pathologies; congenital malformations were detailed based on systems. Congenital malformation were detected in 51,53% of cases, of which 51,50% cardiac malformation, 21,03% neural tube defects and central nervous system malformations, 10,30% pulmonary malformation, 7,30% malformations of the urogenital system, 3,43% malformations of the musculoskeletal system and 1,72% malformations of the face. Cerebral hemorrhage was finding in 93,81% of cases, of which 6,60% with the dilatation of the ventricular system. The role of fetal autopsy remains very important in order to clearly identify some other defects in terminated fetuses. Parents can also be better informed about the possible risks in future pregnancies with the help of the findings received through fetal autopsy so that they can take necessary precautions. A larger number of cases is required for a more accurate evaluation.
Keywords: Autopsy, Fetal diseases, Congenital malformation, Prenatal diagnosis
References: 1. Sloan EP, Kirsh S, Mowbray M: Viewing the fetus following termination of pregnancy for fetal anomaly. JOGNN 2008, 37: 395-404
2. Dickinson JE, Prime DK, Charles AK: The role of autopsy following pregnancy termination for fetal abnormality. ANZJOG 2007, 47: 445-449
3. Nielsen LA, Maroun LL, Broholm H, Laursen H, Graem N: Neural tube defect and associated anomalies in a fetal perinatal autopsy series. APMIS 2006, 114:239-46
4. Bourke J, Bower C, Blair E, Charles A, Knuiman M: Thre effect of termination of pregnancy for fetal abnormalites on trends in mortality to one year of age in Western Australia. Paediatr Perinat Epidemiol 2005, 19:284-293
5. Ceylaner S, Ceylaner G, Gunyeli I, Ekici E, Tug M, Taner D, Ekerbicer H, Mollamahmutoğlu L, Danişman N: Postmortem evaluation of 220 prenataly diagnoses fetuses with neural tube defect detection of associated anomalies in a Turkish population. Prenat Diagn 2006, 26: 147–153
6. Corabian P. Guidelines for investigation stillbirths: an update of a systematic review. J Obstet Gynaecol Can 2007;29:560–7.
7. Gordijn SJ, Erwich JJ, Khong TY. (2002). Value of perinatal autopsy: critique. Pediatr Dev Pathol 2002;5:480–8.
8. Grover N. Congenital malformations in Shimla. Indian J Pediatr. 2000;67:249-51.
*Correspondence: