Journal Info

Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

Ranking and Indexing

Rank: CNCSIS C (code 292) since 2010

International Database: Index Copernicus Journal Master List Value (2010): 4.66

Who's Online

We have 8 guests online

Index Databases

Written by C. Ülgüt, L. Păiuşan, P. Deme   
Read full article
Authors: C. Ülgüt, L. Păiuşan, P. Deme
Affiliation: “Vasile Goldis” Western University of Arad
Abstract: Hormone-related cancers account for almost 30% of all cancer cases. Thanks to the continuous desquamation of cervical epithelium and maintenance of the estrogen responsiveness to old age, cervical-vaginal smears can be a means to study the activity of estrogen in the body because they are the only hormone able to determine the complete differentiation of cervical epithelium. This paper aims to highlight and explain, according to the latest data from the literature, cytological appearance of cervico-vaginal smears of postmenopausal women. Study was conducted at Departament of Pathology of the Hospital of Obstetrics and Gynecology "Salvator Vuia" Arad during 2007-2013. In 40% of the cases analyzed, there was a non-atrophic cervical smear, superficial and intermediate type, and in 60% of cases, atrophic cervical smears, basal and parabasal type. The ability of estrogen to stimulate the development of hormone-injury is a certainty, endocrine therapy is widely used to counteract the tumorigenic effects of estrogen. The etiology of hormone-related lesions in the female reproductive tract is not known, however an important role in the development of the disease that is played by long acting estrogen unopposed by the progestogen.
References: 1. Abushab S, Balan R, Cotuniu C. Endometrial hyperplasias immunohistochemical aspects Rev Med Chir Soc Med Nat Iasi; 2007, 111(1):216-20;
2. Baak JP, Mutter GL, Robboy S et al. The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer; 2005, 103(11):2304-2312;
3. Bala S., Florescu M., Simionescu C., Firoiu C., - Imunoexpresia RE si RP in hiperplazia si carcinoamele endometriale. Al V –lea Simpozion de Morfologie Microscopica- Craiova(12-15mai) 2005;
4. Firoiu C, Simionescu C, Stanculescu D, Cheznoiu F, Stefan A. Histopathological Study of Epithelial Metaplasias in Endometrial Hyperplasia- Current Health Sciences Journal- vol. 35. No. 1, 2009;
5. Gorodeski GI. 1996 The cervical cycle. In: Adashi EY, Rock JA, Rosenwaks Z, eds. Reproductive endocrinology, surgery, and technology. Philadelphia and New York: Lippincott-Raven Publishers; 301–324;
6. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., Smigal, C. and Thun, M.J. 2006. Cancer statistics, 2006. American Cancer Society 56: 106-130;
7. Jeffery, P., Murray, R., Yeh, A., McNamara, J., Duncan, R., Francis, G., Herington, A.C. and Chopin, L. 2005. Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines. Endocrine Related Cancer 12: 839-850;
8. Lungulescu Drăgan M., Citodiagnostic cu metoda de colorare rapidă APT-Drăgan, Editura de Vest, Timişoara, 2004;
9. Mazur Michael T, Kurman Robert J, Diagnosis of Endometrial Biopsies and Curettings. A Practical Approach. Springer Science+Business Media, Inc, Second Edition, 2005;