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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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International Database: Index Copernicus Journal Master List Value (2010): 4.66

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ALBUMINOTHERAPY AND HEPARINOTHERAPY RESISTANCE IN EXTENDED ENTERO-MEZENTERIC ISCHEMIA (CLINICAL CASE) PDF Print E-mail

ALBUMINOTHERAPY AND HEPARINOTHERAPY RESISTANCE IN EXTENDED ENTERO-MEZENTERIC ISCHEMIA (CLINICAL CASE)

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Title:ALBUMINOTHERAPY AND HEPARINOTHERAPY RESISTANCE IN EXTENDED ENTERO-MEZENTERIC ISCHEMIA (CLINICAL CASE)
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Article_Title:ALBUMINOTHERAPY AND HEPARINOTHERAPY RESISTANCE IN EXTENDED ENTERO-MEZENTERIC ISCHEMIA (CLINICAL CASE)
Authors:NICOLESCU CRISTIAN MIRCEA1,2, NICOLESCU LAURA1,2, TURLE LAVINIA1, PANTEA VETURIA ELISABETA 1,2 , MOLDOVAN SILVIU2 , POP ALEXANDRU1, DAMIAN GRATIAN1
Affiliation:1„Vasile Goldis” West University of Arad,
2Arad County Emergency Hospital
Abstract:We present a case for a patient, age 82, for which a surgical emergency intervention was undertaken, preoperative diagnosis was acute occlusive abdomen. Surgery revealed extended intestinal loop necrosis patient went enlarged enterectomy. After surgery heparin is administered, 5000IU initially bolus, then slow continuous intravenous using the injectomat, the administered doses requiring continuous incremental increases to get the hypocoagulation desired status. After 48 hours from starting treatment, the phenomenon of resistance to heparin was considered, intervention with fresh frozen plasma (without stopping the heparin therapy) was undertaken, afterwards patient evolution being subsequently favorable both in terms of clinical condition and laboratory data.
Keywords:heparin, antithrombin III, activated prothrombin time, albumin
References:1. Anderson JAM, Saenko EL. Heparin resistance. Br J Anaesth. 2002;
2. Avidan MS, Levy JH, Scholz J, Delphin E, Rosseel PM, Howie MB, et al. A phase III, double blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass. Anesthesiology. 2005;
3. Avidan MS, Levy JH, van Aken H, Feneck RO, Latimer RD, Ott E, et al. Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2005;
4. Williams MR, D’Ambra AB, Beck JR, Spanier TB, Morales DL, Helman DN, et al. A randomized trial of antithrombin concentrate for treatment of heparin resistance. Ann Thorac Surg. 2000;
5. Spiess BD. Treating heparin resistance with antithrombin or fresh frozen plasma. Ann Thorac Surg.2008;
6. Cheng CC, Choi L, Cheema Z, Silva MB. Acute mesenteric ischemia. In: Cameron JL, Cameron AM, eds. Current Surgical Therapy. 11th ed. Philadelphia, PA: Elsevier Saunders; 2014;
7. Hauser SC. Vascular diseases of the gastrointestinal tract. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016;
8. Roline CE, Reardon RF. Disorders of the small intestine. In: Marx JA, Hockberger RS, Walls RM eds. Rosen's Emergency Medicine. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014;
9. Ghidirim Gh., Mişin I., Brânză M., Şor E., Crăciun I. Tomografia computerizată în evaluarea ischemiei mezenterice acute. În: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale. Chișinău, 2011;
10. Ghidirim Gh., Mişin I., Pleşco E., Crăciun I., Cazacu D. Markerii ischemiei mezenteriale acute. În:Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale. Chișinău, 2012;
11. Crăciun I., Ghidirim Gh., Mişin I., Gagauz I., Şor Elina, Tromboza acută a venelor mezenterice. În:Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale. Chișinău, 2012;
12. Ghidirim G., Mişin I., Crăciun I., Zastavniţchi G. Damage control surgery în ischemia mezenterială acută: studiu pilot. În: Chirurgia. București, România, 2010;
13. Ghidirim Gh., Mişin I., Crăciun I. Managementul chirurgical al ischemiei mezenteriale acute. În: a XXXII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeşu” şi a V-a Conferinţă Internaţională de Chirurghie. Volum de Rezumate. Piatra Neamţ, România;
14. Ghidirim Gh., Mişin I., Crăciun I. Opţiune chirurgicală în tratamentul ischemie mezenteriale acute. În: Chirurgia. Supl.1. București, România, 2011.
Read_full_article:pdf/vol19/iss1/4 JMA 2016 - REZISTENTA LA HEPARINOTERAPIE LA PACIENTA CU INFART ENTERO (1).pdf
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Article Title:ALBUMINOTHERAPY AND HEPARINOTHERAPY RESISTANCE IN EXTENDED ENTERO-MEZENTERIC ISCHEMIA (CLINICAL CASE)
Authors:NICOLESCU CRISTIAN MIRCEA1,2, NICOLESCU LAURA1,2, TURLE LAVINIA1, PANTEA VETURIA ELISABETA 1,2 , MOLDOVAN SILVIU2 , POP ALEXANDRU1, DAMIAN GRATIAN1
Affiliation:1„Vasile Goldis” West University of Arad,
2Arad County Emergency Hospital
Abstract:We present a case for a patient, age 82, for which a surgical emergency intervention was undertaken, preoperative diagnosis was acute occlusive abdomen. Surgery revealed extended intestinal loop necrosis patient went enlarged enterectomy. After surgery heparin is administered, 5000IU initially bolus, then slow continuous intravenous using the injectomat, the administered doses requiring continuous incremental increases to get the hypocoagulation desired status. After 48 hours from starting treatment, the phenomenon of resistance to heparin was considered, intervention with fresh frozen plasma (without stopping the heparin therapy) was undertaken, afterwards patient evolution being subsequently favorable both in terms of clinical condition and laboratory data.
Keywords:heparin, antithrombin III, activated prothrombin time, albumin
References:1. Anderson JAM, Saenko EL. Heparin resistance. Br J Anaesth. 2002;
2. Avidan MS, Levy JH, Scholz J, Delphin E, Rosseel PM, Howie MB, et al. A phase III, double blind, placebo-controlled, multicenter study on the efficacy of recombinant human antithrombin in heparin-resistant patients scheduled to undergo cardiac surgery necessitating cardiopulmonary bypass. Anesthesiology. 2005;
3. Avidan MS, Levy JH, van Aken H, Feneck RO, Latimer RD, Ott E, et al. Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2005;
4. Williams MR, D’Ambra AB, Beck JR, Spanier TB, Morales DL, Helman DN, et al. A randomized trial of antithrombin concentrate for treatment of heparin resistance. Ann Thorac Surg. 2000;
5. Spiess BD. Treating heparin resistance with antithrombin or fresh frozen plasma. Ann Thorac Surg.2008;
6. Cheng CC, Choi L, Cheema Z, Silva MB. Acute mesenteric ischemia. In: Cameron JL, Cameron AM, eds. Current Surgical Therapy. 11th ed. Philadelphia, PA: Elsevier Saunders; 2014;
7. Hauser SC. Vascular diseases of the gastrointestinal tract. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016;
8. Roline CE, Reardon RF. Disorders of the small intestine. In: Marx JA, Hockberger RS, Walls RM eds. Rosen's Emergency Medicine. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014;
9. Ghidirim Gh., Mişin I., Brânză M., Şor E., Crăciun I. Tomografia computerizată în evaluarea ischemiei mezenterice acute. În: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale. Chișinău, 2011;
10. Ghidirim Gh., Mişin I., Pleşco E., Crăciun I., Cazacu D. Markerii ischemiei mezenteriale acute. În:Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale. Chișinău, 2012;
11. Crăciun I., Ghidirim Gh., Mişin I., Gagauz I., Şor Elina, Tromboza acută a venelor mezenterice. În:Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe medicale. Chișinău, 2012;
12. Ghidirim G., Mişin I., Crăciun I., Zastavniţchi G. Damage control surgery în ischemia mezenterială acută: studiu pilot. În: Chirurgia. București, România, 2010;
13. Ghidirim Gh., Mişin I., Crăciun I. Managementul chirurgical al ischemiei mezenteriale acute. În: a XXXII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeşu” şi a V-a Conferinţă Internaţională de Chirurghie. Volum de Rezumate. Piatra Neamţ, România;
14. Ghidirim Gh., Mişin I., Crăciun I. Opţiune chirurgicală în tratamentul ischemie mezenteriale acute. În: Chirurgia. Supl.1. București, România, 2011.
*Correspondence: