Journal Info

Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Rank: CNCSIS C (code 292) since 2010

International Database: Index Copernicus Journal Master List Value (2010): 4.66

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Systematic identification of active ingredients of Silybum marianum seed PDF Print E-mail
Written by Nagy L., Kuki A., Deak G., Biri B., Nagy M., Zsuga M., Keki S.   
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Article Title: Systematic identification of active ingredients of Silybum marianum seed
Authors: Lajos Nagy, Ákos Kuki, Gyögy Deák, Bernadett Biri, Miklós Nagy, Miklós Zsuga, Sándor Kéki*
Affiliation: Department of Applied Chemistry, University of Debrecen
Abstract: Silybum Marianum seed and its extract Silymarin are widely used to treat and prevent many liver diseases such as
cirrhosis. Due to other biological effects (antitumor, antioxidant, cytotoxic activities) numerous Silymarin content
drugs (Silegon, Legalon etc.) are commercially available worldwide. Thus the development of applicable extraction
and separation methods has become sorely needed as well as the improvement of analytical methods (HPLC,
UPLC, HPLC-, UPLC-MS and MS/MS) for these flavonolignans in order to realize a unified quality control. This
paper reviews some extraction and separation methods as well as the fragmentation patterns of different active
components of Silymarin under MS/MS conditions.
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