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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Pharmacology of Silybum marianum and its active constituents. Therapeutic activity – part 2 PDF Print E-mail
Written by Herman H., Pilat L., Mihali C., Popescu C., Turcus V., Ardelean A., Ardelean G., Mariasiu T., Popa C., Hermenean A.   
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Article Title: Pharmacology of Silybum marianum and its active constituents. Therapeutic activity – part 2
Authors: Hildegard Herman1, Luminita Pilat2, Ciprian Mihali1, Cristina Popescu1, Violeta Turcus3, Aurel
Ardelean3, Ardelean Gavril3, Teodora Mariasiu2, Calin Popa2, Anca Hermenean1,2*
Affiliation: 1“Vasile Goldis” Western University of Arad, Institute of Life Sciences, Arad, Romania
2“Vasile Goldis” Western University of Arad, Faculty of Medicine, Pharmacy and Dentistry, Arad, Romania
3“Vasile Goldis” Western University of Arad, Faculty of Natural Sciences, Arad, Romania
Abstract: Silymarin, a flavonolignan from ‘milk thistle’ (Sylibum marianum) plant is used from ancient times as a
hepatoprotective drug. Along the hepatoprotective action silymarin owns also other actions as antioxidant, antilipid
peroxidative, antifibrotic, anti-inflamatory, immunomodulatory, liver regenerating, etc. In Part 1 of this article
we reviewed the milk thistle’s benefic effects in gastrointestinal disorders and its antitumoral activities. Part 2
covers other applications of sylimarin such as antioxidant, antiinflamatory agent, nephroprotector, radiation and
skin protector. It was also studied its neuro-psihiatric and cardiac action.
Keywords: silymarin, oxidative stress, antioxidant, neuroprotection, T cell activation
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*Correspondence: Anca Hermenean, “Vasile Goldis” Western University of Arad, Institute of Life Sciences, no. 86 Liviu Rebreanu St., 310414, Arad, Romania, Tel. +40257212111, Fax. +40257212111, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it