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Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Solubility increasing experiments of sylimarin with cyclodextrins PDF Print E-mail
Written by Fenyvesi F., Petervari M., Nagy L., Keki S., Zsuga M., Bacskay I., Kiss T., Varadi J., Feher P., Ujhelyi Z., Reti-Nagy K., Vecsernyes M.   
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Article Title: Solubility increasing experiments of sylimarin with cyclodextrins
Authors: Ferenc Fenyvesi1, Mátyás Pétervári 1, Lajos Nagy2, Sándor Kéki2, Miklós Zsuga2, Ildikó
Bácskay1, Tímea Kiss1, Judit Váradi1, Pálma Fehér1, Zoltán Ujhelyi1, Katalin Réti-Nagy1,
Miklós Vecsernyés1*
Affiliation: 1Department of Pharmaceutical Technology, University of Debrecen, Debrecen, Hungary
2Department of Applied Chemistry, University of Debrecen, Debrecen, Hungary
Abstract: Silymarin formulations with high bioavailability are required for the treatment hepatic disorders.
Silymarin, the dry extract of Silybum Marianum is water insoluble and its oral bioavailability is limited.
Cyclodextrins are widely used solubility and absorption enhancers therefore we applied the cyclodextrin
nano-encapsulation for the improvement of silymarin solubility. Hydroxylpropyl-β-cyclodextrin (HPBCD),
randomly methylated β-cyclodextrin (RAMEB), 2,6-di-O-methyl β-cyclodextrin (DIMEB) and Quaternary amino
β-cyclodextrin polymer (QABCDP) were used as host molecules. Sylimarin-cyclodextrin complexes were
prepared in 1:20 mass ratio and we found that each cyclodextrin was able to increase the water solubility
of silymarin. The solutions were stable, thus we can conclude that these cyclodextrins are suitable for the
formulations of sylimarin with increased bioavailability.
Keywords: silymarin, cyclodextrins, solubility, mass spectrometry, HPLC
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*Correspondence: Miklós Vecsernyés, University of Debrecen, Debrecen, Faculty of Pharmacy, Department of Pharmaceutical
Technology, Egyetem square 1. 4010. Po. Box.: 78. Debrecen, Hungary. +36-30-512-900/22630. E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it