| Abstract Title: |
Statins therapeutic implications in stroke |
| Authors: |
Lavinia Codruta Gligor, Razvan Gligor, Virginia Gligor |
| Affiliation: |
Farmacology Department, “Vasile Goldis” Western University Arad, Romania |
| Abstract text: |
Statins, 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors, are drugs used to reduce coronary heart disease incidence due to their serum LDL cholesterol-lowering actions. Besides this role statins play an important role in primary and secondary stroke prevention and transient ischemic attack. To achieve this effect involved both decreased serum LDL cholesterol (LDLc concentration reduction of 10% reduced risk for all stroke by 15.6%) and statins pleiotropic effects. Decreased serum LDL cholesterol carries a neuroprotective effect by reducing the heart attack risk, by lowering blood pressure and by anti-atherosclerotic effect. Pleiotropic effects acting through improving cerebrovascular reactivity achieved by improving endothelial function (increased availability of nitric oxide and improving vascular relaxation), through anti-inflammatory effect, antiplatelet and antiproliferative effect. Reducing stroke risk caused by statins occurs mainly in people at high risk (hypertension, coronary heart disease and diabetes), and also in patients with normal cholesterol serum. |
| Keywords: |
statins, stroke, LDL cholesterol, pleiotropic effects, primary and secondary prevention |
| Presentation type: |
Poster |
| Correspondence: |
no. 1 Feleacului St. Arad, Romania |
| Email: |
gligor_serban@yahoo.com |
