Journal Info

Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Rank: CNCSIS C (code 292) since 2010

International Database: Index Copernicus Journal Master List Value (2010): 4.66

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CHARACTERIZATION OF INCLUSION COMPLEXES FORMED BY 4-METHYLBENZYLIDENE CAMPHOR WITH β – CYCLODEXTRIN, HYDROXYPROPYL – β – CYCLODEXTRIN AND HYDROXYPROPYL – α – CYCLODEXTRIN IN 1:2 MOLAR RATIO PDF Print E-mail
Written by Sbora R.,Budura E.,Nitulescu G.,Balaci T.   
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Article Title: CHARACTERIZATION OF INCLUSION COMPLEXES FORMED BY 4-METHYLBENZYLIDENE CAMPHOR WITH β – CYCLODEXTRIN, HYDROXYPROPYL – β – CYCLODEXTRIN AND HYDROXYPROPYL – α – CYCLODEXTRIN IN 1:2 MOLAR RATIO
Authors: RALUCA SBORA¹, EMMA ADRIANA BUDURA²*, GEORGE MIHAI NIŢULESCU³, TEODORA BALACI², DUMITRU LUPULEASA²
Affiliation: University of Medicine and Pharmacy „Carol Davila” Bucharest,
Faculty of Pharmacy, 6 Traian Vuia St., 020956, Bucharest, Romania
¹ PhD Student, Pharmaceutical Technology Department
² Pharmaceutical Technology Department
³ Pharmaceutical Chemistry Department
Abstract: The aim of the present study was to confirm the formation of inclusion complexes between 4-Methylbenzylidene camphor and beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and hydroxypropyl-alfa-cyclodextrin, using lyophilization technique. The inclusion complexes were subjected to physicochemical characterizations in comparison with the simple physical mixtures prepared in the same 1:2 (4-Methylbenzylidene camphor : cyclodextrin) molar ratio. The complexes were evaluated by the scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). The inclusion complexes between 4-Methylbenzylidene camphor and beta-cyclodextrins, in 1:2 molar ratio, found better in all the studied parameters in comparison with the complexes prepared with alfa-cyclodextrin, probably due to the 4-Methylbenzylidene camphor molecule size which fits better in beta-cyclodextrins than in alfa-cyclodextrins cavity.
Keywords: 4-Methylbenzylidene camphor, beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin, hydroxypropyl-alfa-cyclodextrin, inclusion complex, lyophilization.
References: Budura Emma Adriana, Dumitru Lupuleasa, Corina Aramă, Mihai Niţulescu, Teodora Balaci, Preparation and characterization of inclusion complexes formed between simvastatin and hydroxypropyl-β-cyclodextrin, Farmacia, 2011: vol. 59, 4 : 512 – 530
Budura Emma Adriana, Dumitru Lupuleasa, Corina Aramă, Mihai Niţulescu, Victoria Hîrjău, Influence of the method of preparation on physicochemical characteristics of 1:1 simvastatin – β-cyclodextrin inclusion complex, Studia Universitatis „Vasile Goldiş”, Seria Ştiinţele Vieţii, 2011: vol. 21, 3 : 469-477
Loftsson T., Brewster M., Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci., 85, 1017–1025, 1996.
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*Correspondence: Corresponding author: Emma Adriana Budura, University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, Pharmaceutical Technology Department, No. 6 Traian Vuia St., 020956, Bucharest, Romania, Tel. +40-(21)- 3180740, email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it