Journal Info

Title: Jurnal Medical Aradean (Arad Medical Journal)
Abbreviated title: J. Med. Ar.
Publisher: "Vasile Goldis" University Press
Owner: Western University "Vasile Goldis" Arad, Romania
ISSN: 1224-3744
e-ISSN: 2067-7790

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Rank: CNCSIS C (code 292) since 2010

International Database: Index Copernicus Journal Master List Value (2010): 4.66

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Written by Osser G., Avram C., Murg S., Pletea I.,Pallag A.,   
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Authors:Osser Gyongyi1, Cecilia Avram4, Murg Sergiu2, Pletea Movileanu Ioana Maria3,
Annamaria Pallag2, Hulbar Aurelia1, Maria Orodan4
Affiliation:1"Vasile Goldiş" Western University, the Faculty of Pharmacy, Arad, L Rebreanu street
2The University of Oradea, the Faculty of Medicine, Pharmacy and Dental Medicine
3University of Medicine and Farmacy Carol Davila Bucharest
4"Vasile Goldiş" Western University, the Faculty of Medicine, Arad, L Rebreanu street
Abstract:The discovery of statins has led to significant progress in both primary and secondary prevention of coronary heart disease. Although the angiographic changes following statin therapy were modest, the clinical benefits associated with therapy were significant. Numerous clinical trials have correlated the reduction in blood cholesterol induced by these compounds by reducing the number of major coronary events as well as reducing overall mortality in coronary patients
Keywords:statins, UV spectrum, heart disease, cholesterol
References:1. Hunninghake D.B. - HMG-CoA reductase inhibitors, Curr. Opin. Lipidol., 1992, 3: 22-8
2. Ghinghină Carmen, Enache Roxana – Dislipidemia şi riscul cardiovascular: de la factorii clasici la noile fracţiuni lipidice, Stetoscop, Mai 2006, Anul 5, Nr. 50, pag. 20-23
3. Pârvulescu V-N, şi colab. – Dislipidemiile şi relaţia lor cu patologia generală, Practica Medicală, 2007, Vol. 2, Nr. 4(8), pag. 254-260
4. Rusu Emilia, Cheţa DM – Trigliceridele şi riscul cardiovascular, Stetoscop, Anul 6, Nr. 61, Aprilie 2007, pag. 16-20
5. Efthimiades A. – Rosuvastatin and cardiovascular disease: did the strongest statin hold the initial promises?, Angiology, 2008, 59: 62S-64S
6. Vaughan C.J., Gotto A.M., Basson C.T. - The evolving role of statins in the management of atherosclerosis, J. Am. Coll. Cardiol., 2000, 35: 1-10
7. Bellosta S., Ferri N., Bernini F., Paoletti R., Corsini A. - Non-lipid-related effects of statins, Ann. Med., 2000, 32: 164-176
8. Lennernas H., Fager G. - Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors: similarities and differences, Clin. Pharmacokinet., 1997, 32: 403-425
9. Corsini A., Bellosta S., Baetta R., Fumagalli R., Bernini F. - New insights into the pharmacodynamics and pharmacokinetic properties of statins, Pharmacol. Ther., 1999, 84: 413-28
10. Sehayek E., Butbul E., Avner R. - Enhanced cellular metabolism of very low density lipoprotein by simvastatin: a novel mechanism of action of HMG-CoA reductase inhibitors, Eur. J. Clin. Invest., 1994, 24: 173-8
11. Blum C.B. - Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Am. J. Cardiol., 1994, 73: 3D-11D
12. Rizzo M., Rini GB, Berneis R. – Effects of statins, fibrates, rosuvastatin and ezetimibe beyond cholesterol: the modulation of LDL size and subcalsses in high-risk patients, Adv. Ther., 2007, 575-582
13. Thavendiranathan P., bagal A., Brookhart A., et al. – Primary prevention of cardiovascular diseases with statin therapy. A meta-analysis of randomized controlled trials, Arch. Intern. Med., 2006, 166: 2307-2313
14. Afilalo J., Majdan AA, Eisenberg MJ – Intensive statin therapy in acute coronary syndromes and stable coronary heart disease: a comparative meta-analysis of randomised controlled trials, Heart, 2007, 93: 914-921
15. Fauchier L., Pierre B., de Labriolle A., et al – Antiarrhythmic effect of statin therapy and atrial fibrillation. A meta-analysis of randomized controlled trials, J. Amer. Coll. Cardiol., 2008, 51: 828-835
16. Blumenthal RS. - Statins: effective antiatherosclerotic therapy, Am. Heart. J., 2000, 139: 577-83
17. Kostner G.M., Gavish D., Leopold B., Bolzano K., Weintraub M.S., Breslow J.L. - HMG-CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels, Circulation, 1989, 80: 1313-1319
18. Stein E.A., Lane M., Laskarzewski P. - Comparison of statins in hypertriglyceridemia, Am. J. Cardiol., 1998, 81: 66B-69B
19. Gaw A., Packard C.J., Murray E.F. - Effects of simvastatin on apoB metabolism and LDL subfraction distribution, Arterioscler. Thromb., 1993, 13: 170-89
20. Marais A.D., Naumova R.P., Firth J.C., Penny C., Neuwirth C.K., Thompson G.R. - Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia, J. Lipid Res., 1997, 38: 2071-2078
21. Raal F.J., Pilcher G.J., Illingworth D.R., Pappu A.S., Stein E.A., et al. - Expanded dose simvastatin is effective in homozygous familial hypercholesterolemia, Atherosclerosis, 1997, 135: 249-256
22. Hoffman R., Brook G.J., Aviram M. - Hypolipidemic drugs reduce lipoprotein susceptibility to undergo lipid peroxidation: in vitro and ex vivo studies, Atherosclerosis, 1992, 93: 105-13
23. Chen L., Haught W.H., Yang B. - Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine, J. Am. Coll. Cardiol., 1997, 30: 569-75
24. Aviram M., Hussein O., Rosenblat M., Schlezinger S., Hayek T., Keidar S.- Interactions of platelets, macrophages, and lipoproteins in hypercholesterolemia: antiatherogenic effects of HMG-CoA reductase inhibitor therapy, J. Cardiovasc. Pharmacol., 1998, 31: 39-45,
25. Pietsch A., Erl W., Lorenz R.L. - Lovastatin reduces the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells, Biochem. Pharmacol., 52: 433, 1996
26. Bernini F., Didoni G., Bonfadini G., Bellosta S., Fumagalli R. - Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages, Atherosclerosis, 1993, 104: 19-26
27. Bellosta S., Via D., Canavesi M., Pfister P., Fumagalli R., Paoletti R. - HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages, Arterioscler. Thromb. Vasc. Biol., 1998, 18: 1671-8
28. Ballantyne C.M., Herd J.A., Dunn J.K., Jones P.H., Farmer J.A., Gotto A.M.J. - Effects of lipid lowering therapy on progression of coronary and carotid artery disease, Curr. Opin. Lipidol., 1997, 8: 354-361
29. Libby P. – Atherosclerosis: the new view, Sci. Amer., 2002, 286: 47-55
30. Libby P. – The molecular mechanisms of the thrombotic complications of atherosclerosis, J. Intern. Med., 2008, 263: 517-527
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