METFORMIN VS NO METFORMIN DIABETES TREATMENT FOR PATIENTS WITH CLINICAL ANEMIA

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Article Title: METFORMIN VS NO METFORMIN DIABETES TREATMENT FOR PATIENTS WITH CLINICAL ANEMIA
Authors: Alexandru Fica Mircea Onel1, Coralia Adina Cotoraci1, Daniel Răducan3, Nelu-Mihai Trofenciuc1, Verboczki Gabriela Elvira1, Cristina Onel1 , Amorin Remus Popa2
Affiliation: 1″Vasile Goldiş” West University of Arad, Faculty of Medicine
2University of Oradea, Faculty of Medicine
3 “Vasile Goldiş” West University of Arad, Faculty of Pharmacy
Abstract: Metformin, which belongs to the biguanide class, is one of the most generally used oral hypoglycemic agents. Metformin is the only oral anti-diabetic agent associated with improvements in cardiovascular morbidity and mortality and is the cornerstone of medical therapy with lifestyle modification in most patients with diabetes. B12 deficiency has been recognized many years ago as an important side effect in diabetic patients who take metformin for more than 5-10 years (1). This prospective study was performed in Arad County Clinical Emergency Hospital – Hematology Section over 131 patients (aged 18-75 years) diagnosed with type 2 diabetes (termed Lot DZ) admitted to the Arad Hematology Clinic from 2014 to 2015, with a duration of diabetes mellitus of about 1-15 years. The study found that treatment with metformin in patients diagnosed with type II diabetes in combination with cyanobalamin treatment resulted in favorable outcomes.
Keywords: Diabetes, Metformin, therapy, anemia
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*Correspondence: Onel Alexandru Fica Mircea
E-mail: mirceaonel@yahoo.com