EMERGENCY THERAPEUTIC ATTITUDE IN A CASE OF ACUTE INTOXICATION WITH METOCLOPRAMIDE IN THE PEDIATRIC PATIENT

October 14, 2014

EMERGENCY THERAPEUTIC ATTITUDE IN A CASE OF ACUTE INTOXICATION WITH METOCLOPRAMIDE IN THE PEDIATRIC PATIENT

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Title:	EMERGENCY THERAPEUTIC ATTITUDE IN A CASE OF ACUTE INTOXICATION WITH METOCLOPRAMIDE IN THE PEDIATRIC PATIENT
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Article_Title:	EMERGENCY THERAPEUTIC ATTITUDE IN A CASE OF ACUTE INTOXICATION WITH METOCLOPRAMIDE IN THE PEDIATRIC PATIENT
Authors:	Carmen Crisan 1,2, Simona Dumitra 2,1, Adrian Crisan 1,2, Cerasela Buzatu 1,2
Affiliation:	1 Emergency Unit, Emergency Clinical County Hospital, Arad, Romania 2 “Vasile Goldis” Western University, Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
Abstract:	Metoclopramide is authorized through the national procedure in the EU Member States, is a selective dopamine receptor blocker, (D2) and serotonin (5-HT3), inhibits chemoreceptors residing within the trigger, lessens the sensitivity of the nerves that transmit impulses visceral the pylorus and duodenum to induce vomiting. Reevaluation of drugs containing metoclopramide was initiated in December of 2011, at the request of France, in accordance with the provisions of article 31 of Directive (EC) 2001/83/EC. This was followed by another revaluation metoclopramide-containing drugs used in children, made by EU Member States, as provided for in article 45 of Regulation (EC) No. 1901/2006 on medicinal products for pediatric, and after which, in 2010, it has identified the risk of neurological adverse reactions and have been recommended a series of measures to reduce risk to a minimum.
Keywords:	pediatric patient, metoclopramide, adverse reaction
References:	Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. BMJ 1985; 291: 930-2. Dingli K, Morgan R, Leen C. Acute dystonic reaction caused by metoclopramide,versus tetanus. BMJ 2007; 334: 899-900. Fahn S. Systemic therapy of dystonia. Can J Neurol Sci 1987; 14: 528-32. JAEM 2013; 12: 80-4 Işıkay et al.84 Metoclopramide-Induced Acute Dystonic Reaction Gal P, Reed MD. Medications. In Behrman RE, Kliegman RM, Jenson HB, Editors. Nelson Texbook of Pediatrics. 17th ed. Philedelphia: WB, Saunders Company; 2004. p. 2432-2501. HealthCentral. “Side Oral Reglan Efecte.” http://www.healthcentral.com/acid-reflux/find-drug-50680-73.html?ic=4031 Low LC, Goel KM. Metoclopramide poisoning in children. Arch Dis Child 1980; 55: 310-2. Yis U, Ozdemir D, Duman M, Unal N. Metoclopramide induced dystonia in children: two case reports. Eur J Emerg Med 2005; 12: 117-9. Ponte CD, Nappi JM. Review of a new gastrointestinal drug-metoclopramide. Am J Hosp Pharm 1981; 38: 829-33. RxList. “Reglan:. Efecte secundare” http://www.rxlist.com/reglan-drug.htm
Read_full_article:	pdf/vol16/iss1-4/17 JMA 2013 Crisan Carmen – EMERGENCY THERAPEUTIC ATTITUDE IN A CASE OF ACUTE INTOXICATION WITH METOCLOPRAMIDE IN THE PEDIATRIC PATIENT.pdf
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Article Title:	EMERGENCY THERAPEUTIC ATTITUDE IN A CASE OF ACUTE INTOXICATION WITH METOCLOPRAMIDE IN THE PEDIATRIC PATIENT
Authors:	Carmen Crisan 1,2, Simona Dumitra 2,1, Adrian Crisan 1,2, Cerasela Buzatu 1,2
Affiliation:	1 Emergency Unit, Emergency Clinical County Hospital, Arad, Romania 2 “Vasile Goldis” Western University, Faculty of Medicine, Pharmacy and Dental Medicine, Arad, Romania
Abstract:	Metoclopramide is authorized through the national procedure in the EU Member States, is a selective dopamine receptor blocker, (D2) and serotonin (5-HT3), inhibits chemoreceptors residing within the trigger, lessens the sensitivity of the nerves that transmit impulses visceral the pylorus and duodenum to induce vomiting. Reevaluation of drugs containing metoclopramide was initiated in December of 2011, at the request of France, in accordance with the provisions of article 31 of Directive (EC) 2001/83/EC. This was followed by another revaluation metoclopramide-containing drugs used in children, made by EU Member States, as provided for in article 45 of Regulation (EC) No. 1901/2006 on medicinal products for pediatric, and after which, in 2010, it has identified the risk of neurological adverse reactions and have been recommended a series of measures to reduce risk to a minimum.
Keywords:	pediatric patient, metoclopramide, adverse reaction
References:	Bateman DN, Rawlins MD, Simpson JM. Extrapyramidal reactions with metoclopramide. BMJ 1985; 291: 930-2. Dingli K, Morgan R, Leen C. Acute dystonic reaction caused by metoclopramide,versus tetanus. BMJ 2007; 334: 899-900. Fahn S. Systemic therapy of dystonia. Can J Neurol Sci 1987; 14: 528-32. JAEM 2013; 12: 80-4 Işıkay et al.84 Metoclopramide-Induced Acute Dystonic Reaction Gal P, Reed MD. Medications. In Behrman RE, Kliegman RM, Jenson HB, Editors. Nelson Texbook of Pediatrics. 17th ed. Philedelphia: WB, Saunders Company; 2004. p. 2432-2501. HealthCentral. “Side Oral Reglan Efecte.” http://www.healthcentral.com/acid-reflux/find-drug-50680-73.html?ic=4031 Low LC, Goel KM. Metoclopramide poisoning in children. Arch Dis Child 1980; 55: 310-2. Yis U, Ozdemir D, Duman M, Unal N. Metoclopramide induced dystonia in children: two case reports. Eur J Emerg Med 2005; 12: 117-9. Ponte CD, Nappi JM. Review of a new gastrointestinal drug-metoclopramide. Am J Hosp Pharm 1981; 38: 829-33. RxList. “Reglan:. Efecte secundare” http://www.rxlist.com/reglan-drug.htm
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