The correlation between cognitive decline and the incidence and the influence of metabolic…

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Article Title:	The correlation between cognitive decline and the incidence and the influence of metabolic syndrome in elderly subjects with mild cognitive decline
Authors:	Sanda Maria Deme1, Pavel Dan Nanu1, Catalin Dragos Jianu2, Stefania Kory-Calomfirescu3, Dana Simona Ioncu2
Affiliation:	1 “Vasile Goldis” Western University of Arad, Romania 2 “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania 3 “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania
Abstract:	Introduction: The leading causes of irreversible cognitive impairment of late life are Alzheimer disease (AD) and vascular cognitive impairment, vascular dementia (VD). Purpose: To evaluate the incidence and the influence of the metabolic syndrome and metabolic syndrome components on a third age population with mild cognitive impairment and no prior history of cognitive decline. Material and method: The subjects included in this study were admitted in the ER and the Neurology Clinic of “Vasile Goldis” Western University of Arad during a period of 4 years, beginning with 2004. 198 subjects qualified the inclusion/exclusion criteria set for this study. Results: Most of the included subjects were men (56.57%). The average age was 68.3 +/- 4.5 years. The incidence of the MetSy in the study group was 39.39. The most significant cognitive decline is associated to the presence of HTA, leukoaraiosis and age with a mean decrease in MMSE score of -4.556, -4.235 and -3.568. Conclusions: Mild cognitive impairment is more frequent and significantly associated to metabolic syndrome and other vascular risk factors.
Keywords:	cognitive decline, metabolic syndrome, elderly
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*Correspondence:	Sanda Maria Deme, “Vasile Goldiş” Western University Arad, Faculty of Medicine, Department of Neurology, no. 1 Feleacului St., 310396, Arad, Romania, Tel. +40-(257)-212204, Fax. +40-(257)-212204, email: sandademe@yahoo.com